All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 9:50 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs Bal |
| 2 | Kyren Williams | LAR vs NO |
| 3 | James Cook (Q) | Buf @ LAC |
| 4 | Alvin Kamara | NO @ LAR |
| 5 | Rachaad White | TB vs Jax |
| 6 | Breece Hall | NYJ vs Wsh |
| 7 | Isiah Pacheco (GTD) | KC vs LV |
| 8 | Travis Etienne | Jax @ TB |
| 9 | Bijan Robinson | Atl vs Ind |
| 10 | Jonathan Taylor | Ind @ Atl |
| 11 | Raheem Mostert (GTD) | Mia vs Dal |
| 12 | Tony Pollard | Dal @ Mia |
| 13 | Ezekiel Elliott | NE @ Den |
| 14 | Derrick Henry | Ten vs Sea |
| 15 | Joe Mixon | Cin @ Pit |
| 16 | Jahmyr Gibbs | Det @ Min |
| 17 | Saquon Barkley | NYG @ Phi |
| 18 | D'Andre Swift | Phi vs NYG |
| 19 | Austin Ekeler | LAC vs Buf |
| 20 | Josh Jacobs (GTD) | LV @ KC |
| Rank | Player | Match |
| 21 | Chuba Hubbard | Car vs GB |
| 22 | Kenneth Walker III (GTD) | Sea @ Ten |
| 23 | Aaron Jones (GTD) | GB @ Car |
| 24 | Jerome Ford (GTD) | Cle @ Hou |
| 25 | Devin Singletary | Hou vs Cle |
| 26 | David Montgomery | Det @ Min |
| 27 | James Conner | Ari @ Chi |
| 28 | Jaylen Warren | Pit vs Cin |
| 29 | De'Von Achane (GTD) | Mia vs Dal |
| 30 | Javonte Williams | Den vs NE |
| 31 | Ty Chandler | Min vs Det |
| 32 | Najee Harris | Pit vs Cin |
| 33 | Gus Edwards | Bal @ SF |
| 34 | Tyjae Spears | Ten vs Sea |
| 35 | Antonio Gibson | Wsh @ NYJ |
| 36 | Kareem Hunt (GTD) | Cle @ Hou |
| 37 | Brian Robinson Jr. (GTD) | Wsh @ NYJ |
| 38 | A.J. Dillon (GTD) | GB @ Car |
| 39 | D'Onta Foreman | Chi vs Ari |
| 40 | Alexander Mattison (GTD) | Min vs Det |
