All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 11:17 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs TB |
| 2 | Austin Ekeler | LAC @ GB |
| 3 | Travis Etienne | Jax vs Ten |
| 4 | Saquon Barkley (GTD) | NYG @ Wsh |
| 5 | Josh Jacobs | LV @ Mia |
| 6 | Breece Hall | NYJ @ Buf |
| 7 | Jahmyr Gibbs | Det vs Chi |
| 8 | Tony Pollard | Dal @ Car |
| 9 | Aaron Jones (GTD) | GB vs LAC |
| 10 | Derrick Henry | Ten @ Jax |
| 11 | Kenneth Walker III | Sea @ LAR |
| 12 | Brian Robinson Jr. | Wsh vs NYG |
| 13 | Devon Achane | Mia vs LV |
| 14 | Joe Mixon | Cin @ Bal |
| 15 | Javonte Williams | Den vs Min |
| 16 | Raheem Mostert (GTD) | Mia vs LV |
| 17 | Rachaad White | TB @ SF |
| 18 | Isiah Pacheco | KC vs Phi |
| 19 | D'Andre Swift | Phi @ KC |
| 20 | James Conner | Ari @ Hou |
| Rank | Player | Match |
| 21 | Darrell Henderson Jr. | LAR vs Sea |
| 22 | David Montgomery | Det vs Chi |
| 23 | Brian Robinson | Wsh vs NYG |
| 24 | Najee Harris | Pit @ Cle |
| 25 | James Cook | Buf vs NYJ |
| 26 | Jerome Ford | Cle vs Pit |
| 27 | Jaylen Warren | Pit @ Cle |
| 28 | Chuba Hubbard | Car vs Dal |
| 29 | Devin Singletary | Hou vs Ari |
| 30 | Khalil Herbert (GTD) | Chi @ Det |
| 31 | Antonio Gibson (GTD) | Wsh vs NYG |
| 32 | De'Von Achane (GTD) | Mia vs LV |
| 33 | A.J. Dillon | GB vs LAC |
| 34 | Kareem Hunt | Cle vs Pit |
| 35 | Gus Edwards | Bal vs Cin |
| 36 | Dameon Pierce (GTD) | Hou vs Ari |
| 37 | Alexander Mattison (GTD) | Min @ Den |
| 38 | Ty Chandler | Min @ Den |
| 39 | Keaton Mitchell | Bal vs Cin |
| 40 | Miles Sanders | Car vs Dal |
