All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 11:39 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ Cle |
| 2 | Tony Pollard | Dal @ LAC |
| 3 | Bijan Robinson | Atl vs Wsh |
| 4 | Raheem Mostert | Mia vs Car |
| 5 | Austin Ekeler (GTD) | LAC vs Dal |
| 6 | Alvin Kamara | NO @ Hou |
| 7 | Travis Etienne | Jax vs Ind |
| 8 | Josh Jacobs | LV vs NE |
| 9 | Kyren Williams | LAR vs Ari |
| 10 | D'Andre Swift | Phi @ NYJ |
| 11 | Joe Mixon | Cin vs Sea |
| 12 | Isiah Pacheco | KC vs Den |
| 13 | Breece Hall | NYJ vs Phi |
| 14 | David Montgomery | Det @ TB |
| 15 | Kenneth Walker III | Sea @ Cin |
| 16 | Derrick Henry | Ten vs Bal |
| 17 | Alexander Mattison | Min @ Chi |
| 18 | Rachaad White | TB vs Det |
| 19 | James Cook | Buf vs NYG |
| 20 | Rhamondre Stevenson | NE @ LV |
| Rank | Player | Match |
| 21 | Dameon Pierce | Hou vs NO |
| 22 | Brian Robinson Jr. | Wsh @ Atl |
| 23 | Jonathan Taylor | Ind @ Jax |
| 24 | Saquon Barkley (GTD) | NYG @ Buf |
| 25 | Jerome Ford (GTD) | Cle vs SF |
| 26 | Emari Demercado | Ari @ LAR |
| 27 | Miles Sanders (GTD) | Car @ Mia |
| 28 | Javonte Williams | Den @ KC |
| 29 | D'Onta Foreman | Chi vs Min |
| 30 | Zack Moss | Ind @ Jax |
| 31 | Gus Edwards | Bal @ Ten |
| 32 | Ezekiel Elliott | NE @ LV |
| 33 | Jaleel McLaughlin | Den @ KC |
| 34 | Tyler Allgeier | Atl vs Wsh |
| 35 | Chuba Hubbard | Car @ Mia |
| 36 | Tyjae Spears | Ten vs Bal |
| 37 | Jeff Wilson Jr. (GTD) | Mia vs Car |
| 38 | Justice Hill | Bal @ Ten |
| 39 | Kenneth Gainwell | Phi @ NYJ |
| 40 | Roschon Johnson (GTD) | Chi vs Min |
