All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:18 AM ET.
| Rank | Player | Match |
| 1 | Rhamondre Stevenson | NE @ Ari |
| 2 | Austin Ekeler | LAC vs Mia |
| 3 | Christian McCaffrey | SF vs TB |
| 4 | Derrick Henry | Ten vs Jax |
| 5 | Dalvin Cook | Min @ Det |
| 6 | Saquon Barkley (GTD) | NYG vs Phi |
| 7 | Joe Mixon | Cin vs Cle |
| 8 | Nick Chubb | Cle @ Cin |
| 9 | Tony Pollard | Dal vs Hou |
| 10 | James Conner | Ari vs NE |
| 11 | D'Andre Swift | Det vs Min |
| 12 | Ezekiel Elliott | Dal vs Hou |
| 13 | Miles Sanders | Phi @ NYG |
| 14 | Travis Etienne | Jax @ Ten |
| 15 | Latavius Murray | Den vs KC |
| 16 | Najee Harris | Pit vs Bal |
| 17 | Dameon Pierce | Hou @ Dal |
| 18 | Jeff Wilson Jr. | Mia @ LAC |
| 19 | Isiah Pacheco | KC @ Den |
| 20 | D'Onta Foreman | Car @ Sea |
| Rank | Player | Match |
| 21 | Jamaal Williams | Det vs Min |
| 22 | Raheem Mostert | Mia @ LAC |
| 23 | Rachaad White | TB @ SF |
| 24 | Devin Singletary | Buf vs NYJ |
| 25 | James Cook | Buf vs NYJ |
| 26 | Zonovan Knight | NYJ @ Buf |
| 27 | Samaje Perine | Cin vs Cle |
| 28 | Kenneth Walker III | Sea vs Car |
| 29 | Kareem Hunt | Cle @ Cin |
| 30 | Jerick McKinnon | KC @ Den |
| 31 | Michael Carter | NYJ @ Buf |
| 32 | Travis Homer | Sea vs Car |
| 33 | Leonard Fournette (GTD) | TB @ SF |
| 34 | J.K. Dobbins (GTD) | Bal @ Pit |
| 35 | Chuba Hubbard | Car @ Sea |
| 36 | Gus Edwards | Bal @ Pit |
| 37 | Tony Jones Jr. | Sea vs Car |
| 38 | Dontrell Hilliard | Ten vs Jax |
| 39 | Kenneth Gainwell | Phi @ NYG |
| 40 | Alexander Mattison | Min @ Det |
