All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 10:00 AM ET.
| Rank | Player | Match |
| 1 | Josh Jacobs (GTD) | LV vs LAC |
| 2 | Austin Ekeler | LAC @ LV |
| 3 | Christian McCaffrey (GTD) | SF vs Mia |
| 4 | Derrick Henry | Ten @ Phi |
| 5 | Nick Chubb | Cle @ Hou |
| 6 | Saquon Barkley | NYG vs Wsh |
| 7 | Kenneth Walker III | Sea @ LAR |
| 8 | Jonathan Taylor | Ind @ Dal |
| 9 | Dalvin Cook | Min vs NYJ |
| 10 | Aaron Jones | GB @ Chi |
| 11 | Alvin Kamara | NO @ TB |
| 12 | Travis Etienne (GTD) | Jax @ Det |
| 13 | Tony Pollard | Dal vs Ind |
| 14 | David Montgomery | Chi vs GB |
| 15 | Dameon Pierce | Hou vs Cle |
| 16 | Jamaal Williams | Det vs Jax |
| 17 | Joe Mixon (GTD) | Cin vs KC |
| 18 | Miles Sanders | Phi vs Ten |
| 19 | Najee Harris (GTD) | Pit @ Atl |
| 20 | Jeff Wilson Jr. | Mia @ SF |
| Rank | Player | Match |
| 21 | Rachaad White | TB vs NO |
| 22 | Cordarrelle Patterson | Atl vs Pit |
| 23 | Latavius Murray | Den @ Bal |
| 24 | Zonovan Knight | NYJ @ Min |
| 25 | Ezekiel Elliott | Dal vs Ind |
| 26 | Isiah Pacheco | KC @ Cin |
| 27 | Antonio Gibson | Wsh @ NYG |
| 28 | Gus Edwards | Bal vs Den |
| 29 | Brian Robinson | Wsh @ NYG |
| 30 | Leonard Fournette (GTD) | TB vs NO |
| 31 | A.J. Dillon | GB @ Chi |
| 32 | Kyren Williams | LAR vs Sea |
| 33 | D'Andre Swift | Det vs Jax |
| 34 | Kareem Hunt | Cle @ Hou |
| 35 | Jerick McKinnon | KC @ Cin |
| 36 | Samaje Perine | Cin vs KC |
| 37 | Cam Akers | LAR vs Sea |
| 38 | Tyler Allgeier | Atl vs Pit |
| 39 | Raheem Mostert | Mia @ SF |
| 40 | Jaylen Warren | Pit @ Atl |
