All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:49 AM ET.
| Rank | Player | Match |
| 1 | Austin Ekeler | LAC @ Ari |
| 2 | Derrick Henry | Ten vs Cin |
| 3 | Christian McCaffrey | SF vs NO |
| 4 | Josh Jacobs (GTD) | LV @ Sea |
| 5 | Kenneth Walker III | Sea vs LV |
| 6 | Jonathan Taylor (GTD) | Ind vs Pit |
| 7 | Travis Etienne | Jax vs Bal |
| 8 | Nick Chubb | Cle vs TB |
| 9 | Jeff Wilson Jr. | Mia vs Hou |
| 10 | Alvin Kamara | NO @ SF |
| 11 | James Conner | Ari vs LAC |
| 12 | Aaron Jones | GB @ Phi |
| 13 | Najee Harris | Pit @ Ind |
| 14 | Rachaad White | TB @ Cle |
| 15 | Dameon Pierce (GTD) | Hou @ Mia |
| 16 | David Montgomery | Chi @ NYJ |
| 17 | Samaje Perine | Cin @ Ten |
| 18 | Miles Sanders | Phi vs GB |
| 19 | Latavius Murray | Den @ Car |
| 20 | Antonio Gibson | Wsh vs Atl |
| Rank | Player | Match |
| 21 | Michael Carter | NYJ vs Chi |
| 22 | Isiah Pacheco | KC vs LAR |
| 23 | Cordarrelle Patterson | Atl @ Wsh |
| 24 | D'Onta Foreman | Car vs Den |
| 25 | Brian Robinson | Wsh vs Atl |
| 26 | James Robinson | NYJ vs Chi |
| 27 | Kareem Hunt | Cle vs TB |
| 28 | Jerick McKinnon | KC vs LAR |
| 29 | Eli Mitchell | SF vs NO |
| 30 | A.J. Dillon | GB @ Phi |
| 31 | Cam Akers | LAR @ KC |
| 32 | Gus Edwards (GTD) | Bal @ Jax |
| 33 | Kyren Williams | LAR @ KC |
| 34 | Tyler Allgeier | Atl @ Wsh |
| 35 | Raheem Mostert | Mia vs Hou |
| 36 | Kenyan Drake | Bal @ Jax |
| 37 | Chuba Hubbard | Car vs Den |
| 38 | Dontrell Hilliard | Ten vs Cin |
| 39 | Marlon Mack | Den @ Car |
| 40 | Kenneth Gainwell | Phi vs GB |
