All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:40 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs LAC |
| 2 | Saquon Barkley | NYG vs Hou |
| 3 | Derrick Henry | Ten vs Den |
| 4 | Austin Ekeler | LAC @ SF |
| 5 | Alvin Kamara | NO @ Pit |
| 6 | Josh Jacobs | LV vs Ind |
| 7 | Travis Etienne | Jax @ KC |
| 8 | Nick Chubb | Cle @ Mia |
| 9 | Dameon Pierce (GTD) | Hou @ NYG |
| 10 | Jonathan Taylor (GTD) | Ind @ LV |
| 11 | Dalvin Cook | Min @ Buf |
| 12 | Miles Sanders | Phi vs Wsh |
| 13 | Tony Pollard | Dal @ GB |
| 14 | Aaron Jones | GB vs Dal |
| 15 | David Montgomery | Chi vs Det |
| 16 | Jamaal Williams | Det @ Chi |
| 17 | D'Andre Swift | Det @ Chi |
| 18 | Devin Singletary | Buf vs Min |
| 19 | James Conner | Ari @ LAR |
| 20 | Najee Harris | Pit vs NO |
| Rank | Player | Match |
| 21 | Antonio Gibson | Wsh @ Phi |
| 22 | Jeff Wilson Jr. | Mia vs Cle |
| 23 | Raheem Mostert | Mia vs Cle |
| 24 | Kareem Hunt | Cle @ Mia |
| 25 | A.J. Dillon | GB vs Dal |
| 26 | Ezekiel Elliott (GTD) | Dal @ GB |
| 27 | Darrell Henderson | LAR vs Ari |
| 28 | Khalil Herbert | Chi vs Det |
| 29 | Brian Robinson | Wsh @ Phi |
| 30 | Clyde Edwards-Helaire | KC vs Jax |
| 31 | Melvin Gordon | Den @ Ten |
| 32 | Isiah Pacheco | KC vs Jax |
| 33 | Jaylen Warren | Pit vs NO |
| 34 | Latavius Murray | Den @ Ten |
| 35 | Eno Benjamin | Ari @ LAR |
| 36 | Jerick McKinnon | KC vs Jax |
| 37 | Dontrell Hilliard | Ten vs Den |
| 38 | Nyheim Hines | Buf vs Min |
| 39 | Eli Mitchell | SF vs LAC |
| 40 | Rex Burkhead | Hou @ NYG |
