All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 10:07 AM ET.
| Rank | Player | Match |
| 1 | Austin Ekeler | LAC @ Atl |
| 2 | Alvin Kamara | NO vs Bal |
| 3 | Derrick Henry | Ten @ KC |
| 4 | Josh Jacobs | LV @ Jax |
| 5 | Aaron Jones | GB @ Det |
| 6 | Travis Etienne | Jax vs LV |
| 7 | Rhamondre Stevenson | NE vs Ind |
| 8 | Joe Mixon | Cin vs Car |
| 9 | Dalvin Cook | Min @ Wsh |
| 10 | Kenneth Walker III | Sea @ Ari |
| 11 | Leonard Fournette | TB vs LAR |
| 12 | D'Onta Foreman | Car @ Cin |
| 13 | Raheem Mostert | Mia @ Chi |
| 14 | D'Andre Swift (GTD) | Det vs GB |
| 15 | David Montgomery | Chi vs Mia |
| 16 | Jamaal Williams | Det vs GB |
| 17 | Deon Jackson | Ind @ NE |
| 18 | Cordarrelle Patterson | Atl vs LAC |
| 19 | Devin Singletary | Buf @ NYJ |
| 20 | Antonio Gibson | Wsh vs Min |
| Rank | Player | Match |
| 21 | Michael Carter | NYJ vs Buf |
| 22 | James Conner (GTD) | Ari vs Sea |
| 23 | Kenyan Drake | Bal @ NO |
| 24 | Clyde Edwards-Helaire | KC vs Ten |
| 25 | Eno Benjamin | Ari vs Sea |
| 26 | A.J. Dillon | GB @ Det |
| 27 | Brian Robinson | Wsh vs Min |
| 28 | Darrell Henderson | LAR @ TB |
| 29 | Khalil Herbert | Chi vs Mia |
| 30 | Isiah Pacheco | KC vs Ten |
| 31 | Nyheim Hines | Buf @ NYJ |
| 32 | Tyler Allgeier | Atl vs LAC |
| 33 | Damien Harris (GTD) | NE vs Ind |
| 34 | James Robinson (GTD) | NYJ vs Buf |
| 35 | Rachaad White | TB vs LAR |
| 36 | Dontrell Hilliard | Ten @ KC |
| 37 | Jerick McKinnon | KC vs Ten |
| 38 | Jeff Wilson Jr. | Mia @ Chi |
| 39 | Alexander Mattison | Min @ Wsh |
| 40 | Samaje Perine | Cin vs Car |
