All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:29 AM ET.
| Rank | Player | Match |
| 1 | Saquon Barkley | NYG vs Bal |
| 2 | Austin Ekeler | LAC vs Den |
| 3 | Christian McCaffrey | Car @ LAR |
| 4 | Nick Chubb | Cle vs NE |
| 5 | Leonard Fournette | TB @ Pit |
| 6 | Alvin Kamara | NO vs Cin |
| 7 | Rhamondre Stevenson | NE @ Cle |
| 8 | Aaron Jones | GB vs NYJ |
| 9 | Joe Mixon | Cin @ NO |
| 10 | Dalvin Cook | Min @ Mia |
| 11 | Eno Benjamin | Ari @ Sea |
| 12 | Breece Hall | NYJ @ GB |
| 13 | Kenneth Walker III | Sea vs Ari |
| 14 | Darrell Henderson | LAR vs Car |
| 15 | Miles Sanders | Phi vs Dal |
| 16 | Jeff Wilson | SF @ Atl |
| 17 | Raheem Mostert (GTD) | Mia vs Min |
| 18 | Melvin Gordon (GTD) | Den @ LAC |
| 19 | Najee Harris | Pit vs TB |
| 20 | Deon Jackson | Ind vs Jax |
| Rank | Player | Match |
| 21 | Ezekiel Elliott | Dal @ Phi |
| 22 | J.K. Dobbins | Bal @ NYG |
| 23 | A.J. Dillon | GB vs NYJ |
| 24 | Clyde Edwards-Helaire | KC vs Buf |
| 25 | James Robinson | Jax @ Ind |
| 26 | Devin Singletary | Buf @ KC |
| 27 | Kareem Hunt | Cle vs NE |
| 28 | Travis Etienne | Jax @ Ind |
| 29 | Tony Pollard | Dal @ Phi |
| 30 | Tyler Allgeier | Atl vs SF |
| 31 | Mike Boone | Den @ LAC |
| 32 | Phillip Lindsay | Ind vs Jax |
| 33 | Michael Carter | NYJ @ GB |
| 34 | Rachaad White | TB @ Pit |
| 35 | Alexander Mattison (GTD) | Min @ Mia |
| 36 | Jerick McKinnon | KC vs Buf |
| 37 | Chase Edmonds | Mia vs Min |
| 38 | Mark Ingram | NO vs Cin |
| 39 | Caleb Huntley | Atl vs SF |
| 40 | Joshua Kelley | LAC vs Den |
