All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 1:24 PM ET.
| Rank | Player | Match |
| 1 | Jonathan Taylor | Ind @ Ari |
| 2 | Alvin Kamara | NO vs Mia |
| 3 | Alexander Mattison | Min vs LAR |
| 4 | James Robinson | Jax @ NYJ |
| 5 | Najee Harris | Pit @ KC |
| 6 | Nick Chubb | Cle @ GB |
| 7 | Cordarrelle Patterson | Atl vs Det |
| 8 | Josh Jacobs | LV vs Den |
| 9 | Aaron Jones | GB vs Cle |
| 10 | Joe Mixon | Cin vs Bal |
| 11 | D'Andre Swift (GTD) | Det @ Atl |
| 12 | David Montgomery | Chi @ Sea |
| 13 | Antonio Gibson (GTD) | Wsh @ Phi |
| 14 | Ezekiel Elliott | Dal vs Wsh |
| 15 | Saquon Barkley | NYG @ Phi |
| 16 | James Conner (GTD) | Ari vs Ind |
| 17 | Miles Sanders | Phi vs Wsh |
| 18 | Ronald Jones | TB @ Car |
| 19 | Michael Carter | NYJ vs Jax |
| 20 | Austin Ekeler (GTD) | LAC @ Hou |
| Rank | Player | Match |
| 21 | Clyde Edwards-Helaire | KC vs Pit |
| 22 | Javonte Williams | Den @ LV |
| 23 | Melvin Gordon | Den @ LV |
| 24 | Devonta Freeman | Bal @ Cin |
| 25 | Darrell Henderson | LAR vs Sea |
| 26 | A.J. Dillon | GB vs Cle |
| 27 | Tony Pollard | Dal vs Wsh |
| 28 | Devin Singletary | Buf @ NE |
| 29 | Sony Michel | LAR vs Sea |
| 30 | Rashaad Penny | Sea vs Chi |
| 31 | Justin Jackson | LAC @ Hou |
| 32 | Chase Edmonds | Ari vs Ind |
| 33 | Rex Burkhead | Hou vs LAC |
| 34 | Myles Gaskin | Mia @ NO |
| 35 | Mike Davis | Atl vs Det |
| 36 | Mark Ingram | NO vs Mia |
| 37 | Brandon Bolden | NE vs Buf |
| 38 | Darrel Williams | KC vs Pit |
| 39 | David Johnson (GTD) | Hou vs LAC |
| 40 | Damien Harris (GTD) | NE vs Buf |
