All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:16 AM ET.
| Rank | Player | Match |
| 1 | Alvin Kamara | NO vs Atl |
| 2 | Austin Ekeler | LAC @ Phi |
| 3 | Najee Harris | Pit vs Chi |
| 4 | Dalvin Cook | Min @ Bal |
| 5 | Ezekiel Elliott | Dal vs Den |
| 6 | Darrell Henderson | LAR vs Ten |
| 7 | Aaron Jones | GB @ KC |
| 8 | Nick Chubb | Cle @ Cin |
| 9 | Joe Mixon | Cin vs Cle |
| 10 | Christian McCaffrey (GTD) | Car vs NE |
| 11 | Myles Gaskin | Mia vs Hou |
| 12 | Josh Jacobs | LV @ NYG |
| 13 | Cordarrelle Patterson | Atl @ NO |
| 14 | Devontae Booker | NYG vs LV |
| 15 | Damien Harris | NE @ Car |
| 16 | Chase Edmonds | Ari @ SF |
| 17 | Zack Moss | Buf @ Jax |
| 18 | Darrel Williams | KC vs GB |
| 19 | Eli Mitchell (GTD) | SF vs Ari |
| 20 | Melvin Gordon | Den @ Dal |
| Rank | Player | Match |
| 21 | Khalil Herbert | Chi @ Pit |
| 22 | James Robinson (GTD) | Jax vs Buf |
| 23 | Javonte Williams | Den @ Dal |
| 24 | Tony Pollard | Dal vs Den |
| 25 | Boston Scott | Phi vs LAC |
| 26 | James Conner | Ari @ SF |
| 27 | David Montgomery (GTD) | Chi @ Pit |
| 28 | Jeremy McNichols | Ten @ LAR |
| 29 | Devin Singletary | Buf @ Jax |
| 30 | Mike Davis | Atl @ NO |
| 31 | Adrian Peterson | Ten @ LAR |
| 32 | Carlos Hyde | Jax vs Buf |
| 33 | Chuba Hubbard | Car vs NE |
| 34 | Devonta Freeman | Bal vs Min |
| 35 | David Johnson | Hou @ Mia |
| 36 | Salvon Ahmed | Mia vs Hou |
| 37 | Kenyan Drake | LV @ NYG |
| 38 | A.J. Dillon | GB @ KC |
| 39 | Kenneth Gainwell | Phi vs LAC |
| 40 | Derrick Gore | KC vs GB |
