All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 10:27 AM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Ten @ Ind |
| 2 | Dalvin Cook | Min vs Dal |
| 3 | Alvin Kamara | NO vs TB |
| 4 | Darrell Henderson | LAR @ Hou |
| 5 | D'Andre Swift | Det vs Phi |
| 6 | Najee Harris | Pit @ Cle |
| 7 | Jonathan Taylor | Ind vs Ten |
| 8 | Nick Chubb | Cle vs Pit |
| 9 | Austin Ekeler (GTD) | LAC vs NE |
| 10 | Ezekiel Elliott | Dal @ Min |
| 11 | Joe Mixon | Cin @ NYJ |
| 12 | James Robinson | Jax @ Sea |
| 13 | Chuba Hubbard | Car @ Atl |
| 14 | Cordarrelle Patterson | Atl vs Car |
| 15 | Leonard Fournette | TB @ NO |
| 16 | Antonio Gibson | Wsh @ Den |
| 17 | Darrel Williams | KC vs NYG |
| 18 | Khalil Herbert | Chi vs SF |
| 19 | Damien Harris | NE @ LAC |
| 20 | Devontae Booker | NYG @ KC |
| Rank | Player | Match |
| 21 | Michael Carter | NYJ vs Cin |
| 22 | Kenneth Gainwell | Phi @ Det |
| 23 | Eli Mitchell | SF @ Chi |
| 24 | Alex Collins (GTD) | Sea vs Jax |
| 25 | Javonte Williams | Den vs Wsh |
| 26 | Myles Gaskin | Mia @ Buf |
| 27 | Melvin Gordon | Den vs Wsh |
| 28 | Zack Moss | Buf vs Mia |
| 29 | David Johnson | Hou vs LAR |
| 30 | J.D. McKissic | Wsh @ Den |
| 31 | Devin Singletary | Buf vs Mia |
| 32 | Jamaal Williams (GTD) | Det vs Phi |
| 33 | Mike Davis | Atl vs Car |
| 34 | Tony Pollard | Dal @ Min |
| 35 | Samaje Perine | Cin @ NYJ |
| 36 | Phillip Lindsay | Hou vs LAR |
| 37 | Nyheim Hines | Ind vs Ten |
| 38 | Alexander Mattison | Min vs Dal |
| 39 | Boston Scott | Phi @ Det |
| 40 | Ty Johnson | NYJ vs Cin |
