All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 10:32 AM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Ten vs Buf |
| 2 | Kareem Hunt | Cle vs Ari |
| 3 | Dalvin Cook | Min @ Car |
| 4 | Austin Ekeler | LAC @ Bal |
| 5 | Joe Mixon | Cin @ Det |
| 6 | Aaron Jones | GB @ Chi |
| 7 | Jonathan Taylor | Ind vs Hou |
| 8 | Ezekiel Elliott | Dal @ NE |
| 9 | Najee Harris | Pit vs Sea |
| 10 | D'Andre Swift | Det vs Cin |
| 11 | Darrell Henderson | LAR @ NYG |
| 12 | Antonio Gibson | Wsh vs KC |
| 13 | Khalil Herbert | Chi vs GB |
| 14 | Chuba Hubbard | Car vs Min |
| 15 | Josh Jacobs | LV @ Den |
| 16 | Devontae Booker | NYG vs LAR |
| 17 | Melvin Gordon | Den vs LV |
| 18 | Darrel Williams | KC @ Wsh |
| 19 | Javonte Williams | Den vs LV |
| 20 | Chase Edmonds | Ari @ Cle |
| Rank | Player | Match |
| 21 | Zack Moss | Buf @ Ten |
| 22 | Jamaal Williams | Det vs Cin |
| 23 | Damien Harris | NE vs Dal |
| 24 | Devin Singletary | Buf @ Ten |
| 25 | Latavius Murray | Bal vs LAC |
| 26 | James Conner | Ari @ Cle |
| 27 | Tony Pollard | Dal @ NE |
| 28 | Nyheim Hines | Ind vs Hou |
| 29 | Jerick McKinnon | KC @ Wsh |
| 30 | A.J. Dillon | GB @ Chi |
| 31 | Alexander Mattison | Min @ Car |
| 32 | Mark Ingram | Hou @ Ind |
| 33 | Alex Collins | Sea @ Pit |
| 34 | Sony Michel | LAR @ NYG |
| 35 | J.D. McKissic | Wsh vs KC |
| 36 | David Johnson | Hou @ Ind |
| 37 | Chris Carson (Out) | Sea @ Pit |
| 38 | Brandon Bolden | NE vs Dal |
| 39 | Ty'Son Williams | Bal vs LAC |
| 40 | Chris Evans | Cin @ Det |
