All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 1:15 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs NYJ |
| 2 | Dalvin Cook | Min @ Cin |
| 3 | Alvin Kamara | NO vs GB |
| 4 | Derrick Henry | Ten vs Ari |
| 5 | Aaron Jones | GB @ NO |
| 6 | Jonathan Taylor | Ind vs Sea |
| 7 | Austin Ekeler (GTD) | LAC @ Wsh |
| 8 | Joe Mixon | Cin vs Min |
| 9 | Antonio Gibson | Wsh vs LAC |
| 10 | Ezekiel Elliott | Dal @ TB |
| 11 | Saquon Barkley | NYG vs Den |
| 12 | Najee Harris | Pit @ Buf |
| 13 | Nick Chubb | Cle @ KC |
| 14 | Clyde Edwards-Helaire | KC vs Cle |
| 15 | Chris Carson | Sea @ Ind |
| 16 | James Robinson | Jax @ Hou |
| 17 | David Montgomery | Chi @ LAR |
| 18 | Miles Sanders | Phi @ Atl |
| 19 | Mike Davis | Atl vs Phi |
| 20 | D'Andre Swift | Det vs SF |
| Rank | Player | Match |
| 21 | Darrell Henderson (GTD) | LAR vs Chi |
| 22 | Raheem Mostert | SF @ Det |
| 23 | Josh Jacobs | LV vs Bal |
| 24 | Gus Edwards | Bal @ LV |
| 25 | Chase Edmonds | Ari @ Ten |
| 26 | Damien Harris | NE vs Mia |
| 27 | Myles Gaskin | Mia @ NE |
| 28 | Javonte Williams | Den @ NYG |
| 29 | Kareem Hunt | Cle @ KC |
| 30 | Melvin Gordon (GTD) | Den @ NYG |
| 31 | Trey Sermon | SF @ Det |
| 32 | Leonard Fournette | TB vs Dal |
| 33 | Ronald Jones | TB vs Dal |
| 34 | Zack Moss | Buf vs Pit |
| 35 | Kenyan Drake | LV vs Bal |
| 36 | Devin Singletary | Buf vs Pit |
| 37 | James Conner | Ari @ Ten |
| 38 | Jamaal Williams | Det vs SF |
| 39 | Sony Michel | LAR vs Chi |
| 40 | A.J. Dillon | GB @ NO |
