All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:17 AM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Ten @ Hou |
| 2 | Jonathan Taylor | Ind vs Jax |
| 3 | Austin Ekeler | LAC @ KC |
| 4 | Aaron Jones | GB @ Chi |
| 5 | Nick Chubb | Cle vs Pit |
| 6 | David Montgomery | Chi vs GB |
| 7 | D'Andre Swift | Det vs Min |
| 8 | Chris Carson | Sea @ SF |
| 9 | Melvin Gordon | Den vs LV |
| 10 | Josh Jacobs | LV @ Den |
| 11 | Myles Gaskin | Mia @ Buf |
| 12 | Ezekiel Elliott | Dal @ NYG |
| 13 | Antonio Gibson | Wsh @ Phi |
| 14 | Ronald Jones | TB vs Atl |
| 15 | David Johnson | Hou vs Ten |
| 16 | Jeff Wilson | SF vs Sea |
| 17 | Boston Scott | Phi vs Wsh |
| 18 | Kenyan Drake | Ari @ LAR |
| 19 | Alexander Mattison | Min @ Det |
| 20 | Nyheim Hines | Ind vs Jax |
| Rank | Player | Match |
| 21 | Ty Montgomery | NO @ Car |
| 22 | J.K. Dobbins | Bal @ Cin |
| 23 | Ty Johnson | NYJ @ NE |
| 24 | Dare Ogunbowale | Jax @ Ind |
| 25 | Kareem Hunt | Cle vs Pit |
| 26 | J.D. McKissic | Wsh @ Phi |
| 27 | Wayne Gallman | NYG vs Dal |
| 28 | Rodney Smith | Car vs NO |
| 29 | Giovani Bernard | Cin vs Bal |
| 30 | Malcolm Brown | LAR vs Ari |
| 31 | Gus Edwards (que) | Bal @ Cin |
| 32 | Darrel Williams | KC vs LAC |
| 33 | Sony Michel | NE vs NYJ |
| 34 | Ito Smith | Atl @ TB |
| 35 | Tony Pollard | Dal @ NYG |
| 36 | James Conner | Pit @ Cle |
| 37 | Jamaal Williams | GB @ Chi |
| 38 | Devin Singletary | Buf vs Mia |
| 39 | James White | NE vs NYJ |
| 40 | Darwin Thompson | KC vs LAC |
