All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 7:55 AM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Ten @ Jax |
| 2 | Dalvin Cook | Min @ TB |
| 3 | Aaron Jones | GB @ Det |
| 4 | Austin Ekeler | LAC vs Atl |
| 5 | James Robinson | Jax vs Ten |
| 6 | Chris Carson | Sea vs NYJ |
| 7 | Alvin Kamara | NO @ Phi |
| 8 | Mike Davis | Car vs Den |
| 9 | David Montgomery | Chi vs Hou |
| 10 | Ezekiel Elliott (GTD) | Dal @ Cin |
| 11 | Nick Chubb | Cle vs Bal |
| 12 | James Conner | Pit @ Buf |
| 13 | Ronald Jones | TB vs Min |
| 14 | Jonathan Taylor | Ind @ LV |
| 15 | Kenyan Drake (que) | Ari @ NYG |
| 16 | Duke Johnson | Hou @ Chi |
| 17 | Wayne Gallman | NYG vs Ari |
| 18 | Raheem Mostert | SF vs Wsh |
| 19 | Josh Jacobs (GTD) | LV vs Ind |
| 20 | D'Andre Swift (GTD) | Det vs GB |
| Rank | Player | Match |
| 21 | Clyde Edwards-Helaire | KC @ Mia |
| 22 | Miles Sanders | Phi vs NO |
| 23 | Giovani Bernard | Cin vs Dal |
| 24 | J.D. McKissic | Wsh @ SF |
| 25 | Todd Gurley (GTD) | Atl @ LAC |
| 26 | Melvin Gordon | Den @ Car |
| 27 | Kareem Hunt | Cle vs Bal |
| 28 | Nyheim Hines | Ind @ LV |
| 29 | DeAndre Washington | Mia vs KC |
| 30 | J.K. Dobbins | Bal @ Cle |
| 31 | Leonard Fournette | TB vs Min |
| 32 | Jamaal Williams | GB @ Det |
| 33 | Chase Edmonds | Ari @ NYG |
| 34 | Devin Singletary | Buf vs Pit |
| 35 | Peyton Barber | Wsh @ SF |
| 36 | Latavius Murray | NO @ Phi |
| 37 | Phillip Lindsay | Den @ Car |
| 38 | Zack Moss | Buf vs Pit |
| 39 | Frank Gore (que) | NYJ @ Sea |
| 40 | Jeff Wilson | SF vs Wsh |
