All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 3:38 AM ET.
| Rank | Player | Match |
| 1 | Dalvin Cook | Min vs Jax |
| 2 | Derrick Henry | Ten vs Cle |
| 3 | Austin Ekeler | LAC vs NE |
| 4 | James Robinson | Jax @ Min |
| 5 | Aaron Jones | GB vs Phi |
| 6 | Myles Gaskin (GTD) | Mia vs Cin |
| 7 | Alvin Kamara | NO @ Atl |
| 8 | Miles Sanders | Phi @ GB |
| 9 | Nick Chubb | Cle @ Ten |
| 10 | Chris Carson | Sea vs NYG |
| 11 | Devontae Booker | LV @ NYJ |
| 12 | Raheem Mostert | SF vs Buf |
| 13 | Clyde Edwards-Helaire | KC vs Den |
| 14 | David Montgomery (GTD) | Chi vs Det |
| 15 | Antonio Gibson | Wsh @ Pit |
| 16 | Wayne Gallman | NYG @ Sea |
| 17 | Kenyan Drake | Ari vs LAR |
| 18 | David Johnson (GTD) | Hou vs Ind |
| 19 | Jonathan Taylor | Ind @ Hou |
| 20 | Kareem Hunt | Cle @ Ten |
| Rank | Player | Match |
| 21 | Damien Harris | NE @ LAC |
| 22 | Giovani Bernard | Cin @ Mia |
| 23 | Nyheim Hines | Ind @ Hou |
| 24 | Frank Gore | NYJ vs LV |
| 25 | Todd Gurley (GTD) | Atl vs NO |
| 26 | James White | NE @ LAC |
| 27 | Jamaal Williams | GB vs Phi |
| 28 | Darrell Henderson | LAR @ Ari |
| 29 | Kerryon Johnson | Det @ Chi |
| 30 | Adrian Peterson | Det @ Chi |
| 31 | Latavius Murray | NO @ Atl |
| 32 | Melvin Gordon | Den @ KC |
| 33 | Carlos Hyde (que) | Sea vs NYG |
| 34 | Devin Singletary | Buf @ SF |
| 35 | J.D. McKissic | Wsh @ Pit |
| 36 | Chase Edmonds | Ari vs LAR |
| 37 | Zack Moss | Buf @ SF |
| 38 | Cam Akers | LAR @ Ari |
| 39 | Phillip Lindsay (GTD) | Den @ KC |
| 40 | Jalen Richard | LV @ NYJ |
