All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 2:51 AM ET.
| Rank | Player | Match |
| 1 | Alvin Kamara | NO vs SF |
| 2 | Dalvin Cook | Min @ Chi |
| 3 | Aaron Jones | GB vs Jax |
| 4 | Miles Sanders (GTD) | Phi @ NYG |
| 5 | Josh Jacobs | LV vs Den |
| 6 | James Robinson | Jax @ GB |
| 7 | James Conner | Pit vs Cin |
| 8 | Mike Davis | Car vs TB |
| 9 | Duke Johnson | Hou @ Cle |
| 10 | Nick Chubb | Cle vs Hou |
| 11 | Antonio Gibson | Wsh @ Det |
| 12 | Giovani Bernard | Cin @ Pit |
| 13 | Leonard Fournette | TB @ Car |
| 14 | Jerick McKinnon | SF @ NO |
| 15 | Darrell Henderson | LAR vs Sea |
| 16 | Kareem Hunt | Cle vs Hou |
| 17 | D'Andre Swift | Det vs Wsh |
| 18 | Chase Edmonds | Ari vs Buf |
| 19 | Melvin Gordon | Den @ LV |
| 20 | Ronald Jones | TB @ Car |
| Rank | Player | Match |
| 21 | J.D. McKissic | Wsh @ Det |
| 22 | Jamaal Williams | GB vs Jax |
| 23 | Wayne Gallman | NYG vs Phi |
| 24 | Kenyan Drake (que) | Ari vs Buf |
| 25 | Phillip Lindsay (GTD) | Den @ LV |
| 26 | Devin Singletary | Buf @ Ari |
| 27 | J.K. Dobbins | Bal @ NE |
| 28 | Malcolm Brown | LAR vs Sea |
| 29 | Latavius Murray | NO vs SF |
| 30 | Zack Moss | Buf @ Ari |
| 31 | DeeJay Dallas | Sea @ LAR |
| 32 | Matt Breida (que) | Mia vs LAC |
| 33 | Joshua Kelley | LAC @ Mia |
| 34 | Travis Homer (GTD) | Sea @ LAR |
| 35 | James White | NE vs Bal |
| 36 | Troymaine Pope (que) | LAC @ Mia |
| 37 | JaMycal Hasty | SF @ NO |
| 38 | Rex Burkhead | NE vs Bal |
| 39 | Kalen Ballage | LAC @ Mia |
| 40 | Damien Harris | NE vs Bal |
