All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 10:09 AM ET.
| Rank | Player | Match |
| 1 | Alvin Kamara | NO vs Car |
| 2 | Kareem Hunt | Cle @ Cin |
| 3 | Derrick Henry | Ten vs Pit |
| 4 | Ezekiel Elliott | Dal @ Wsh |
| 5 | Mike Davis | Car @ NO |
| 6 | Josh Jacobs | LV vs TB |
| 7 | Chris Carson | Sea @ Ari |
| 8 | Todd Gurley | Atl vs Det |
| 9 | James Conner | Pit @ Ten |
| 10 | David Montgomery | Chi @ LAR |
| 11 | Ronald Jones | TB @ LV |
| 12 | Clyde Edwards-Helaire | KC @ Den |
| 13 | James Robinson | Jax @ LAC |
| 14 | Jamaal Williams | GB @ Hou |
| 15 | David Johnson | Hou vs GB |
| 16 | Antonio Gibson | Wsh vs Dal |
| 17 | Giovani Bernard | Cin vs Cle |
| 18 | Devin Singletary | Buf @ NYJ |
| 19 | Kenyan Drake | Ari vs Sea |
| 20 | Darrell Henderson | LAR vs Chi |
| Rank | Player | Match |
| 21 | Jerick McKinnon | SF @ NE |
| 22 | Justin Jackson (que) | LAC vs Jax |
| 23 | Melvin Gordon | Den vs KC |
| 24 | D'Andre Swift | Det @ Atl |
| 25 | James White | NE vs SF |
| 26 | Joshua Kelley | LAC vs Jax |
| 27 | Latavius Murray | NO vs Car |
| 28 | Adrian Peterson | Det @ Atl |
| 29 | J.D. McKissic | Wsh vs Dal |
| 30 | Phillip Lindsay | Den vs KC |
| 31 | Damien Harris | NE vs SF |
| 32 | Chase Edmonds | Ari vs Sea |
| 33 | Frank Gore | NYJ vs Buf |
| 34 | Rex Burkhead | NE vs SF |
| 35 | Aaron Jones (que) | GB @ Hou |
| 36 | Le'Veon Bell | KC @ Den |
| 37 | A.J. Dillon | GB @ Hou |
| 38 | La'Mical Perine | NYJ vs Buf |
| 39 | Zack Moss | Buf @ NYJ |
| 40 | Duke Johnson | Hou vs GB |
