All position ranks are: QB RB WR TE FLEX D
These rankings were updated as of Sun 10:18 AM ET.
| Rank | Player | Match |
| 1 | Alvin Kamara | NO vs LAC |
| 2 | Ezekiel Elliott | Dal vs NYG |
| 3 | Dalvin Cook | Min @ Sea |
| 4 | Clyde Edwards-Helaire | KC vs LV |
| 5 | Kareem Hunt (GTD) | Cle vs Ind |
| 6 | Miles Sanders | Phi @ Pit |
| 7 | Mike Davis | Car @ Atl |
| 8 | Josh Jacobs | LV @ KC |
| 9 | Chris Carson | Sea vs Min |
| 10 | James Conner | Pit vs Phi |
| 11 | James Robinson | Jax @ Hou |
| 12 | David Johnson | Hou vs Jax |
| 13 | Todd Gurley | Atl vs Car |
| 14 | Joe Mixon (que) | Cin @ Bal |
| 15 | Jonathan Taylor | Ind @ Cle |
| 16 | Raheem Mostert (que) | SF vs Mia |
| 17 | Kenyan Drake | Ari @ NYJ |
| 18 | Melvin Gordon | Den @ NE |
| 19 | Antonio Gibson | Wsh vs LAR |
| 20 | Myles Gaskin | Mia @ SF |
| Rank | Player | Match |
| 21 | Jerick McKinnon | SF vs Mia |
| 22 | Joshua Kelley | LAC @ NO |
| 23 | Mark Ingram | Bal vs Cin |
| 24 | Devonta Freeman | NYG @ Dal |
| 25 | James White | NE vs Den |
| 26 | Damien Harris | NE vs Den |
| 27 | Rex Burkhead | NE vs Den |
| 28 | Le'Veon Bell | NYJ vs Ari |
| 29 | Darrell Henderson | LAR @ Wsh |
| 30 | Derrick Henry | Ten vs Buf |
| 31 | Chase Edmonds | Ari @ NYJ |
| 32 | Latavius Murray | NO vs LAC |
| 33 | Nyheim Hines | Ind @ Cle |
| 34 | Duke Johnson | Hou vs Jax |
| 35 | Justin Jackson | LAC @ NO |
| 36 | Malcolm Brown | LAR @ Wsh |
| 37 | Chris Thompson | Jax @ Hou |
| 38 | Phillip Lindsay (GTD) | Den @ NE |
| 39 | J.D. McKissic | Wsh vs LAR |
| 40 | Brian Hill | Atl vs Car |
