These rankings were updated as of Sun 8:54 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs NO |
| 2 | Ezekiel Elliott | Dal vs Wsh |
| 3 | Aaron Jones | GB @ Det |
| 4 | Saquon Barkley | NYG vs Phi |
| 5 | Alvin Kamara | NO @ Car |
| 6 | Derrick Henry | Ten @ Hou |
| 7 | Nick Chubb | Cle @ Cin |
| 8 | Miles Sanders | Phi @ NYG |
| 9 | Le'Veon Bell | NYJ @ Buf |
| 10 | Kenyan Drake | Ari @ LAR |
| 11 | Joe Mixon | Cin vs Cle |
| 12 | Marlon Mack | Ind @ Jax |
| 13 | DeAndre Washington | Oak @ Den |
| 14 | Devonta Freeman | Atl @ TB |
| 15 | Phillip Lindsay | Den vs Oak |
| 16 | Austin Ekeler | LAC @ KC |
| 17 | Melvin Gordon | LAC @ KC |
| 18 | Sony Michel (que) | NE vs Mia |
| 19 | Raheem Mostert | SF @ Sea |
| 20 | Damien Williams | KC vs LAC |
| Rank | Player | Match |
| 21 | Ryquell Armstead | Jax vs Ind |
| 22 | Ronald Jones | TB vs Atl |
| 23 | James White | NE vs Mia |
| 24 | Todd Gurley | LAR vs Ari |
| 25 | David Montgomery (GTD) | Chi @ Min |
| 26 | Travis Homer | Sea vs SF |
| 27 | Malcolm Brown | LAR vs Ari |
| 28 | Devin Singletary | Buf vs NYJ |
| 29 | Adrian Peterson | Wsh @ Dal |
| 30 | Mike Boone | Min vs Chi |
| 31 | Kareem Hunt | Cle @ Cin |
| 32 | Carlos Hyde (GTD) | Hou vs Ten |
| 33 | Justice Hill | Bal vs Pit |
| 34 | Patrick Laird | Mia @ NE |
| 35 | Kerryon Johnson | Det vs GB |
| 36 | Jalen Richard | Oak @ Den |
| 37 | Gus Edwards | Bal vs Pit |
| 38 | Latavius Murray | NO @ Car |
| 39 | Jaylen Samuels | Pit @ Bal |
| 40 | Benny Snell | Pit @ Bal |
