All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sun 8:40 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car @ NO |
| 2 | Alvin Kamara | NO vs Car |
| 3 | Nick Chubb | Cle vs Mia |
| 4 | Saquon Barkley | NYG @ Chi |
| 5 | Leonard Fournette | Jax @ Ten |
| 6 | Derrick Henry | Ten vs Jax |
| 7 | Ezekiel Elliott | Dal @ NE |
| 8 | Le'Veon Bell | NYJ vs Oak |
| 9 | Chris Carson | Sea @ Phi |
| 10 | Josh Jacobs | Oak @ NYJ |
| 11 | Aaron Jones | GB @ SF |
| 12 | Todd Gurley | LAR vs Bal |
| 13 | Tevin Coleman | SF vs GB |
| 14 | Jaylen Samuels | Pit @ Cin |
| 15 | David Montgomery | Chi vs NYG |
| 16 | Phillip Lindsay | Den @ Buf |
| 17 | Brian Hill | Atl vs TB |
| 18 | Mark Ingram | Bal @ LAR |
| 19 | Joe Mixon | Cin vs Pit |
| 20 | Devin Singletary | Buf vs Den |
| Rank | Player | Match |
| 21 | James White | NE vs Dal |
| 22 | Kareem Hunt | Cle vs Mia |
| 23 | Sony Michel | NE vs Dal |
| 24 | Miles Sanders | Phi vs Sea |
| 25 | Ronald Jones | TB @ Atl |
| 26 | Jamaal Williams | GB @ SF |
| 27 | Tarik Cohen | Chi vs NYG |
| 28 | Kalen Ballage | Mia @ Cle |
| 29 | Latavius Murray | NO vs Car |
| 30 | Derrius Guice | Wsh vs Det |
| 31 | Royce Freeman | Den @ Buf |
| 32 | Bo Scarbrough | Det @ Wsh |
| 33 | J.D. McKissic | Det @ Wsh |
| 34 | Raheem Mostert | SF vs GB |
| 35 | Adrian Peterson (que) | Wsh vs Det |
| 36 | Benny Snell | Pit @ Cin |
| 37 | James Conner (que) | Pit @ Cin |
| 38 | Frank Gore | Buf vs Den |
| 39 | Patrick Laird | Mia @ Cle |
| 40 | Rex Burkhead | NE vs Dal |