All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 4:21 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Ten |
| 2 | Dalvin Cook | Min @ KC |
| 3 | Ezekiel Elliott | Dal @ NYG |
| 4 | Saquon Barkley | NYG vs Dal |
| 5 | Leonard Fournette | Jax @ Hou |
| 6 | DeAndre Hopkins | Hou vs Jax |
| 7 | Nick Chubb | Cle @ Den |
| 8 | Aaron Jones | GB @ LAC |
| 9 | Chris Carson | Sea vs TB |
| 10 | Le'Veon Bell | NYJ @ Mia |
| 11 | Chris Godwin | TB @ Sea |
| 12 | Tyler Lockett | Sea vs TB |
| 13 | Mike Evans | TB @ Sea |
| 14 | Amari Cooper | Dal @ NYG |
| 15 | Keenan Allen | LAC vs GB |
| 16 | Josh Jacobs | Oak vs Det |
| 17 | Kenny Golladay | Det @ Oak |
| 18 | Derrick Henry | Ten @ Car |
| 19 | Marlon Mack | Ind @ Pit |
| 20 | Stefon Diggs | Min @ KC |
| 21 | Julian Edelman (que) | NE @ Bal |
| 22 | Davante Adams (que) | GB @ LAC |
| 23 | Odell Beckham | Cle @ Den |
| 24 | Tyreek Hill | KC vs Min |
| 25 | Allen Robinson | Chi @ Phi |
| 26 | D.J. Chark | Jax @ Hou |
| 27 | Darren Waller | Oak vs Det |
| 28 | Austin Ekeler | LAC vs GB |
| 29 | JuJu Smith-Schuster | Pit vs Ind |
| 30 | Courtland Sutton | Den vs Cle |
| 31 | Melvin Gordon | LAC vs GB |
| 32 | Hunter Henry | LAC vs GB |
| 33 | Travis Kelce | KC vs Min |
| 34 | Phillip Lindsay | Den vs Cle |
| 35 | Mark Ingram | Bal vs NE |
| Rank | Player | Match |
| 36 | Sony Michel | NE @ Bal |
| 37 | Adam Thielen (que) | Min @ KC |
| 38 | Mark Walton | Mia vs NYJ |
| 39 | John Brown | Buf vs Wsh |
| 40 | David Montgomery | Chi @ Phi |
| 41 | Royce Freeman (GTD) | Den vs Cle |
| 42 | Jaylen Samuels | Pit vs Ind |
| 43 | D.K. Metcalf | Sea vs TB |
| 44 | Michael Gallup | Dal @ NYG |
| 45 | D.J. Moore | Car vs Ten |
| 46 | Evan Engram | NYG vs Dal |
| 47 | Carlos Hyde | Hou vs Jax |
| 48 | Tyrell Williams | Oak vs Det |
| 49 | Marvin Jones | Det @ Oak |
| 50 | Curtis Samuel (que) | Car vs Ten |
| 51 | Alshon Jeffery | Phi vs Chi |
| 52 | Zach Ertz | Phi vs Chi |
| 53 | Mark Andrews | Bal vs NE |
| 54 | Jordan Howard | Phi vs Chi |
| 55 | Jamaal Williams | GB @ LAC |
| 56 | Jarvis Landry | Cle @ Den |
| 57 | James White (que) | NE @ Bal |
| 58 | Mike Williams | LAC vs GB |
| 59 | Jamison Crowder | NYJ @ Mia |
| 60 | Robby Anderson | NYJ @ Mia |
| 61 | Sterling Shepard | NYG vs Dal |
| 62 | Kenny Stills | Hou vs Jax |
| 63 | Preston Williams | Mia vs NYJ |
| 64 | Golden Tate | NYG vs Dal |
| 65 | Devin Singletary | Buf vs Wsh |
| 66 | Danny Amendola | Det @ Oak |
| 67 | DeVante Parker | Mia vs NYJ |
| 68 | Terry McLaurin | Wsh @ Buf |
| 69 | Frank Gore | Buf vs Wsh |
| 70 | LeSean McCoy | KC vs Min |
