All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 4:21 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Ten |
| 2 | Dalvin Cook | Min @ KC |
| 3 | Ezekiel Elliott | Dal @ NYG |
| 4 | Saquon Barkley | NYG vs Dal |
| 5 | Leonard Fournette | Jax @ Hou |
| 6 | Nick Chubb | Cle @ Den |
| 7 | Aaron Jones | GB @ LAC |
| 8 | Chris Carson | Sea vs TB |
| 9 | Le'Veon Bell | NYJ @ Mia |
| 10 | Josh Jacobs | Oak vs Det |
| 11 | Derrick Henry | Ten @ Car |
| 12 | Marlon Mack | Ind @ Pit |
| 13 | Austin Ekeler | LAC vs GB |
| 14 | Melvin Gordon | LAC vs GB |
| 15 | Phillip Lindsay | Den vs Cle |
| 16 | Mark Ingram | Bal vs NE |
| 17 | Sony Michel | NE @ Bal |
| 18 | Mark Walton | Mia vs NYJ |
| 19 | David Montgomery | Chi @ Phi |
| 20 | Royce Freeman (GTD) | Den vs Cle |
| Rank | Player | Match |
| 21 | Jaylen Samuels | Pit vs Ind |
| 22 | Carlos Hyde | Hou vs Jax |
| 23 | Jordan Howard | Phi vs Chi |
| 24 | Jamaal Williams | GB @ LAC |
| 25 | James White (que) | NE @ Bal |
| 26 | Devin Singletary | Buf vs Wsh |
| 27 | Frank Gore | Buf vs Wsh |
| 28 | LeSean McCoy | KC vs Min |
| 29 | Adrian Peterson | Wsh @ Buf |
| 30 | Tarik Cohen | Chi @ Phi |
| 31 | Duke Johnson | Hou vs Jax |
| 32 | James Conner (dou) | Pit vs Ind |
| 33 | Ronald Jones | TB @ Sea |
| 34 | Ty Johnson | Det @ Oak |
| 35 | Miles Sanders (GTD) | Phi vs Chi |
| 36 | Peyton Barber | TB @ Sea |
| 37 | Tra Carson (que) | Det @ Oak |
| 38 | Damien Williams | KC vs Min |
| 39 | Rex Burkhead (que) | NE @ Bal |
| 40 | Nyheim Hines | Ind @ Pit |
