All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 2:38 PM ET.
| Rank | Player | Match |
| 1 | Saquon Barkley | NYG vs Ari |
| 2 | Leonard Fournette | Jax @ Cin |
| 3 | Ezekiel Elliott | Dal vs Phi |
| 4 | Dalvin Cook | Min @ Det |
| 5 | David Johnson (que) | Ari @ NYG |
| 6 | Chris Carson | Sea vs Bal |
| 7 | Le'Veon Bell | NYJ vs NE |
| 8 | Derrick Henry | Ten vs LAC |
| 9 | Aaron Jones | GB vs Oak |
| 10 | Marlon Mack | Ind vs Hou |
| 11 | Kerryon Johnson | Det vs Min |
| 12 | Todd Gurley | LAR @ Atl |
| 13 | Devonta Freeman | Atl vs LAR |
| 14 | Josh Jacobs (GTD) | Oak @ GB |
| 15 | Mark Ingram | Bal @ Sea |
| 16 | Tevin Coleman | SF @ Wsh |
| 17 | Melvin Gordon | LAC @ Ten |
| 18 | Sony Michel | NE @ NYJ |
| 19 | David Montgomery | Chi vs NO |
| 20 | Latavius Murray | NO @ Chi |
| Rank | Player | Match |
| 21 | Joe Mixon | Cin vs Jax |
| 22 | Austin Ekeler | LAC @ Ten |
| 23 | Carlos Hyde | Hou @ Ind |
| 24 | Matt Breida | SF @ Wsh |
| 25 | James White | NE @ NYJ |
| 26 | Devin Singletary | Buf vs Mia |
| 27 | Frank Gore | Buf vs Mia |
| 28 | Kenyan Drake | Mia @ Buf |
| 29 | Jamaal Williams | GB vs Oak |
| 30 | Jordan Howard | Phi @ Dal |
| 31 | Miles Sanders | Phi @ Dal |
| 32 | Tarik Cohen | Chi vs NO |
| 33 | Adrian Peterson (GTD) | Wsh vs SF |
| 34 | Rex Burkhead (que) | NE @ NYJ |
| 35 | Duke Johnson | Hou @ Ind |
| 36 | Ito Smith | Atl vs LAR |
| 37 | Chase Edmonds | Ari @ NYG |
| 38 | Nyheim Hines | Ind vs Hou |
| 39 | Giovani Bernard | Cin vs Jax |
| 40 | Dion Lewis | Ten vs LAC |
