All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Thu 2:13 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey (que) | Car vs TB |
| 2 | Ezekiel Elliott | Dal @ NYJ |
| 3 | Dalvin Cook | Min vs Phi |
| 4 | Alvin Kamara | NO @ Jax |
| 5 | Nick Chubb | Cle vs Sea |
| 6 | Le'Veon Bell | NYJ vs Dal |
| 7 | Leonard Fournette | Jax vs NO |
| 8 | Todd Gurley (que) | LAR vs SF |
| 9 | Aaron Jones | GB vs Det |
| 10 | James Conner | Pit @ LAC |
| 11 | David Johnson (que) | Ari vs Atl |
| 12 | Chris Carson | Sea @ Cle |
| 13 | Kerryon Johnson | Det @ GB |
| 14 | Derrick Henry | Ten @ Den |
| 15 | Devonta Freeman | Atl @ Ari |
| 16 | Melvin Gordon | LAC vs Pit |
| 17 | Mark Ingram | Bal vs Cin |
| 18 | Sony Michel | NE vs NYG |
| 19 | Austin Ekeler | LAC vs Pit |
| 20 | Joe Mixon | Cin @ Bal |
| Rank | Player | Match |
| 21 | Phillip Lindsay | Den vs Ten |
| 22 | Damien Williams | KC vs Hou |
| 23 | Kenyan Drake | Mia vs Wsh |
| 24 | James White | NE vs NYG |
| 25 | Carlos Hyde | Hou @ KC |
| 26 | Jon Hilliman | NYG @ NE |
| 27 | Royce Freeman | Den vs Ten |
| 28 | Matt Breida | SF @ LAR |
| 29 | Chris Thompson | Wsh @ Mia |
| 30 | Tevin Coleman | SF @ LAR |
| 31 | Adrian Peterson | Wsh @ Mia |
| 32 | Ronald Jones | TB @ Car |
| 33 | Jordan Howard | Phi @ Min |
| 34 | Duke Johnson | Hou @ KC |
| 35 | LeSean McCoy | KC vs Hou |
| 36 | Miles Sanders | Phi @ Min |
| 37 | Rex Burkhead (que) | NE vs NYG |
| 38 | Peyton Barber | TB @ Car |
| 39 | Ito Smith | Atl @ Ari |
| 40 | Rashaad Penny | Sea @ Cle |
