All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Thu 2:13 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey (que) | Car vs TB |
| 2 | Ezekiel Elliott | Dal @ NYJ |
| 3 | Dalvin Cook | Min vs Phi |
| 4 | Alvin Kamara | NO @ Jax |
| 5 | Nick Chubb | Cle vs Sea |
| 6 | Le'Veon Bell | NYJ vs Dal |
| 7 | Leonard Fournette | Jax vs NO |
| 8 | Julio Jones (que) | Atl @ Ari |
| 9 | DeAndre Hopkins | Hou @ KC |
| 10 | Todd Gurley (que) | LAR vs SF |
| 11 | Keenan Allen | LAC vs Pit |
| 12 | Aaron Jones | GB vs Det |
| 13 | Cooper Kupp | LAR vs SF |
| 14 | James Conner | Pit @ LAC |
| 15 | David Johnson (que) | Ari vs Atl |
| 16 | Chris Carson | Sea @ Cle |
| 17 | Kerryon Johnson | Det @ GB |
| 18 | Michael Thomas | NO @ Jax |
| 19 | Travis Kelce | KC vs Hou |
| 20 | Derrick Henry | Ten @ Den |
| 21 | Tyreek Hill (que) | KC vs Hou |
| 22 | Amari Cooper (que) | Dal @ NYJ |
| 23 | Odell Beckham | Cle vs Sea |
| 24 | Devonta Freeman | Atl @ Ari |
| 25 | Chris Godwin (que) | TB @ Car |
| 26 | Melvin Gordon | LAC vs Pit |
| 27 | Mark Ingram | Bal vs Cin |
| 28 | Julian Edelman (que) | NE vs NYG |
| 29 | Adam Thielen (Q) | Min vs Phi |
| 30 | Sony Michel | NE vs NYG |
| 31 | Austin Ekeler | LAC vs Pit |
| 32 | Tyler Lockett | Sea @ Cle |
| 33 | Tyler Boyd | Cin @ Bal |
| 34 | Davante Adams (que) | GB vs Det |
| 35 | Kenny Golladay | Det @ GB |
| Rank | Player | Match |
| 36 | Mike Evans | TB @ Car |
| 37 | George Kittle | SF @ LAR |
| 38 | Joe Mixon | Cin @ Bal |
| 39 | Robert Woods | LAR vs SF |
| 40 | Phillip Lindsay | Den vs Ten |
| 41 | Zach Ertz | Phi @ Min |
| 42 | Will Fuller | Hou @ KC |
| 43 | Larry Fitzgerald | Ari vs Atl |
| 44 | Josh Gordon (que) | NE vs NYG |
| 45 | Damien Williams | KC vs Hou |
| 46 | JuJu Smith-Schuster | Pit @ LAC |
| 47 | D.J. Chark | Jax vs NO |
| 48 | D.J. Moore | Car vs TB |
| 49 | Kenyan Drake | Mia vs Wsh |
| 50 | Terry McLaurin | Wsh @ Mia |
| 51 | Courtland Sutton (que) | Den vs Ten |
| 52 | Alshon Jeffery | Phi @ Min |
| 53 | James White | NE vs NYG |
| 54 | Austin Hooper | Atl @ Ari |
| 55 | Calvin Ridley | Atl @ Ari |
| 56 | Mark Andrews (que) | Bal vs Cin |
| 57 | Michael Gallup | Dal @ NYJ |
| 58 | Curtis Samuel | Car vs TB |
| 59 | Jarvis Landry | Cle vs Sea |
| 60 | Stefon Diggs | Min vs Phi |
| 61 | Emmanuel Sanders (que) | Den vs Ten |
| 62 | Carlos Hyde | Hou @ KC |
| 63 | Jon Hilliman | NYG @ NE |
| 64 | Royce Freeman | Den vs Ten |
| 65 | Matt Breida | SF @ LAR |
| 66 | Marquez Valdes-Scantling | GB vs Det |
| 67 | Mike Williams | LAC vs Pit |
| 68 | Golden Tate | NYG @ NE |
| 69 | Chris Thompson | Wsh @ Mia |
| 70 | Marvin Jones | Det @ GB |
