Other position ranks are: Top-25 QBs Top-50 WRs Top-25 TEs Top-70 FLEXs
These rankings were updated as of Wed 5:20 PM ET.
| Rank | Player | Match |
| 1 | Ezekiel Elliott | Dal vs Sea |
| 2 | Melvin Gordon (GTD) | LAC @ Bal |
| 3 | Chris Carson | Sea @ Dal |
| 4 | Marlon Mack | Ind @ Hou |
| 5 | Tarik Cohen | Chi vs Phi |
| 6 | Lamar Miller | Hou vs Ind |
| 7 | Jordan Howard | Chi vs Phi |
| 8 | Gus Edwards | Bal vs LAC |
| 9 | Josh Adams | Phi @ Chi |
| 10 | Austin Ekeler | LAC @ Bal |
| 11 | Darren Sproles | Phi @ Chi |
| 12 | Kenneth Dixon | Bal vs LAC |
| 13 | Nyheim Hines | Ind @ Hou |
| 14 | Wendell Smallwood | Phi @ Chi |
| 15 | Mike Davis | Sea @ Dal |
| 16 | Alfred Blue | Hou vs Ind |
| 17 | Rod Smith | Dal vs Sea |
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| Rank | Player | Match |
| 18 | Rashaad Penny | Sea @ Dal |
| 19 | Justin Jackson | LAC @ Bal |
| 20 | Ty Montgomery | Bal vs LAC |
| 21 | D'Onta Foreman | Hou vs Ind |
| 22 | Jordan Wilkins | Ind @ Hou |
| 23 | Taquan Mizzell | Chi vs Phi |
| 24 | Patrick Ricard | Bal vs LAC |
| 25 | Benny Cunningham | Chi vs Phi |
| 26 | Detrez Newsome | LAC @ Bal |
| 27 | Buddy Howell | Hou vs Ind |
| 28 | Javorius Allen | Bal vs LAC |
| 29 | Boston Scott | Phi @ Chi |
| 30 | De'Lance Turner | Bal vs LAC |
| 31 | Jamize Olawale | Dal vs Sea |
| 32 | Troymaine Pope | LAC @ Bal |
| 33 | Tre Madden | Sea @ Dal |
| 34 | Derek Watt | LAC @ Bal |
| 35 | Michael Burton | Chi vs Phi |
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