These standard ranks are updated as of Dec. 20
Other Week 16 Ranks: Top 20 QBs Top 50 WRs Top 20 TEs
| Rank | Player | Team | Opp |
| 1 | Todd Gurley | LAR | @ARI |
| 2 | Christian McCaffrey | CAR | ATL |
| 3 | Saquon Barkley | NYG | @IND |
| 4 | Nick Chubb | CLE | CIN |
| 5 | Alvin Kamara | NO | PIT |
| 6 | Ezekiel Elliott | DAL | TB |
| 7 | Dalvin Cook | MIN | @DET |
| 8 | Joe Mixon | CIN | @CLE |
| 9 | Phillip Lindsay | DEN | @OAK |
| 10 | Melvin Gordon | LAC | BAL |
| 11 | Leonard Fournette | JAX | @MIA |
| 12 | Chris Carson | SEA | KC |
| 13 | Derrick Henry | TEN | WAS |
| 14 | Marlon Mack | IND | NYG |
| 15 | Jamaal Williams | GB | @NYJ |
| 16 | Tarik Cohen | CHI | @SF |
| 17 | Jaylen Samuels | PIT | @NO |
| 18 | Elijah McGuire | NYJ | GB |
| 19 | Jordan Howard | CHI | @SF |
| 20 | Lamar Miller | HOU | @PHI |
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| Rank | Player | Team | Opp |
| 21 | Tevin Coleman | ATL | @CAR |
| 22 | Sony Michel | NE | BUF |
| 23 | Spencer Ware | KC | @SEA |
| 24 | Gus Edwards | BAL | @LAC |
| 25 | James White | NE | BUF |
| 26 | Kenyan Drake | MIA | JAX |
| 27 | Matt Breida * | SF | CHI |
| 28 | Peyton Barber | TB | @DAL |
| 29 | Damien Williams | KC | @SEA |
| 30 | Adrian Peterson | WAS | @TEN |
| 31 | Wendall Smallwood | PHI | HOU |
| 32 | Kalen Ballage | MIA | JAX |
| 33 | Doug Martin | OAK | DEN |
| 34 | Theo Riddick | DET | MIN |
| 35 | LeSean McCoy* | BUF | @NE |
| 36 | Jalen Richard | OAK | DEN |
| 37 | Zach Zenner | DET | MIN |
| 38 | Dion Lewis | TEN | WAS |
| 39 | Kenneth Dixon | BAL | @LAC |
| 40 | Jeff Wilson | SF | CHI |
*Assuming the player plays
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