Also look at these other Week 6 rankings: RB WR TE FLEX
These ranks are updated as of Oct. 21.
On bye: Lions and Texans
The Cardinals-Rams game will be played in London.
| Rank | Player | Team | Opp |
| 1 | Tom Brady | NE | ATL |
| 2 | Carson Wentz | PHI | WAS |
| 3 | Matt Ryan | ATL | @NE |
| 4 | Drew Brees | NO | @GB |
| 5 | Dak Prescott | DAL | @SF |
| 6 | Marcus Mariota | TEN | @CLE |
| 7 | Cam Newton | CAR | @CHI |
| 8 | Russell Wilson | SEA | @NYG |
| 9 | Kirk Cousins | WAS | @PHI |
| 10 | Jameis Winston | TB | @BUF |
| 11 | Ben Rorthlisberger | PIT | CIN |
| 12 | Jared Goff | LAR | ARI |
| 13 | Tyrod Taylor | BUF | TB |
| 14 | Philip Rivers | LAC | DEN |
| 15 | Brett Hundley | GB | NO |
| 16 | Andy Dalton | CIN | @PIT |
| 17 | Blake Bortles | JAX | @IND |
| 18 | Jacoby Brissett | IND | JAX |
| 19 | Eli Manning | NYG | SEA |
| 20 | Case Keenum | MIN | Bal |
| 21 | Josh McCown | NYJ | @MIA |
| 22 | Carson Palmer | ARI | @LAR |
| 23 | DeShone Kizer | CLE | TEN |
| 24 | Mitchell Trubisky | CHI | CAR |
| 25 | C.J. Beathard | SF | DAL |
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