Also look at these other Week 4 rankings: QB WR TE FLEX
These ranks are updated as of Sept. 27 and will be updated throughout the weekend.
Note: The Saints-Dolphins game will be played in London.
| Rank | Player | Team | Opp |
| 1 | Kareem Hunt | KC | WAS |
| 2 | Ezekiel Elliott | DAL | LAR |
| 3 | Todd Gurley | LAR | @DAL |
| 4 | Dalvin Cook | MIN | DET |
| 5 | Leonard Fournette | JAC | @NYJ |
| 6 | Jordan Howard | CHI | @GB |
| 7 | Le'Veon Bell | PIT | @BAL |
| 8 | Devonta Freeman | ATL | BUF |
| 9 | Carlos Hyde | SF | @ARI |
| 10 | Jay Ajayi | MIA | NO |
| 11 | LeSean McCoy | BUF | @ATL |
| 12 | Ty Montgomery | GB | CHI |
| 13 | C.J. Anderson | DEN | OAK |
| 14 | Christian McCaffrey | CAR | @NE |
| 15 | Melvin Gordon | LAC | PHI |
| 16 | Joe Mixon | CIN | @CLE |
| 17 | Chris Thompson | WAS | @KC |
| 18 | Chris Carson | SEA | IND |
| 19 | LeGarrette Blount | PHI | @LAC |
| 20 | Duke Johnson | CLE | CIN |
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| Rank | Player | Team | Opp |
| 21 | DeMarco Murray | TEN | @HOU |
| 22 | Mike Gillislee | NE | CAR |
| 23 | Jonathan Stewart | CAR | @NE |
| 24 | Tarik Cohen | CHI | @GB |
| 25 | Marshawn Lynch | OAK | @DEN |
| 26 | Alvin Kamara | NO | @MIA |
| 27 | Giovani Bernard | CIN | @CLE |
| 28 | Lamar Miller | HOU | TEN |
| 29 | Ameer Abdullah | DET | @MIN |
| 30 | Isaiah Crowell | CLE | CIN |
| 31 | Mark Ingram | NO | @MIA |
| 32 | Javorius Allen | BAL | PIT |
| 33 | Bilal Powell | NYJ | JAC |
| 34 | Wendell Smallwood | PHI | @LAC |
| 35 | Jamaal Charles | DEN | OAK |
| 36 | Terrance West | BAL | PIT |
| 37 | Andre Ellington | ARI | SF |
| 38 | Frank Gore | IND | @SEA |
| 39 | James White | NE | CAR |
| 40 | Jacquizz Rodgers | TB | NYG |
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