Updated as of Sept. 16.
QUARTERBACKS
Andrew Luck, Indianapolis Colts
Luck has already been ruled out for Week 2, and you can pretty much assume that he will miss Week 3 at this point. Really, there's no telling when his surgically repaired shoulder will be well enough for him to play again. There was a lot of ugly offense all over the NFL in Week 1, but the Colts' offense without Luck looked like it didn't belong in the league. Even with Jacoby Brissett expected to take over for Scott Tolzien, all receivers in Indy need to be sharply downgraded for as long as Luck is out. The only player(s) who should be glad to hear about Luck's absence are those on the Cardinals' defense. They are a phenomenal play in Week 2 after the Colts permitted four sacks, three turnovers, two touchdowns and a safety versus the Rams.
Cam Newton, Carolina Panthers
The man (formerly?) known as Superman will have his practice snaps managed throughout the season as the Panthers try to reduce the amount of strain on his surgically repaired throwing shoulder. As such, Newton was "limited" during Thursday's practice. But he was available for a full session Friday and then taken off Carolina's injury report. He is Levi Andrew's No. 6 QB this week.
Sam Bradford, Minnesota Vikings
Bradford turned in arguably the best game of his career Monday night versus the Saints, posting a career-high 143.0 passer rating. He completed 27 of 32 passes for 346 yards, three scores and no turnovers. He was limited in practice throughout this week by a knee issue and is listed as questionable. There's reason to doubt his ability to play in Sunday's game at Pittsburgh, although he was on the Vikings' team flight to the Steel City. Bradford underwent an MRI this week and will have to look good in his pregame workout in order to get the green light. He is Levi Andrew's No. 19 QB because of that tough matchup.
WIDE RECEIVERS
Odell Beckham Jr., New York Giants
Beckham just wasn't right during pregame warmups in Dallas on Sunday night and was thereby held out of the Giants' season opener. He is more than three weeks removed from suffering a high-ankle sprain but said a few days ago that his injury requires 6-8 weeks of recovery. I'm not sure I buy that since Beckham practiced on Thursday, Friday and Saturday, albeit in limited fashion. He is officially marked as questionable, but the odds of him being active Monday night versus the Lions look pretty good right now. I wouldn't have any qualms about rolling with him in my lineup, even if I didn't have a Monday night replacement option on my roster. He is AJ Schreiver's No. 3 wideout for this week.
Jarvis Landry, Miami Dolphins
Another former LSU wideout, Landry popped up on the injury report Friday after a knee injury kept him from practicing fully. He is listed as questionable but, despite some swelling in that knee, he is still expected to be a full-go versus the Chargers. He is just a WR3 for that matchup.
Golden Tate, Detroit Lions
Tate was wearing a splint over his left ring finger earlier this week, but no worries; he was a full participant in Friday's practice and will play his usual role as a dangerous slot receiver versus the Giants. Schreiver has ranked him as his No. 25 WR.
Allen Robinson, Jacksonville Jaguars
Robinson's 2017 season lasted all of three plays before it was ended by a torn left ACL. Marqise Lee and Allen Hurns will be asked to pick up the slack out wide, but most of all, Robinson's injury will probably make the Jaguars more run-dependant. Jacksonville rolled out a 39-21 run-pass split last week. It certainly helped that they led the Texans by double digits for the entire second half, but Leonard Fournette better be prepared to handle a boatload of touches each week going forward. There just aren't many other dependable options in this offense sans Robinson. Fournette racked up 124 yards and a touchdown on 29 touches (26 carries, three receptions) in Week 1.
Danny Amendola, New England Patriots
Unsurprisingly, Amendola will not play in Week 2. He remains in the league's concussion protocol nine days after suffering his latest brain injury versus the Chiefs, which was at least Amendola's third concussion as a pro. Oh, and he picked up a knee injury last week as well. Brandin Cooks and Chris Hogan will be the Patriots' top wideouts versus the Saints. Amendola's absence should open the door for deep threat Phillip Dorsett to play more snaps as well as more targets for the Pats' handful of pass-catching running backs.
John Brown, Arizona Cardinals
Brown is being held back by a quadriceps injury once again. He was unable to practice at all this week, won't play versus the Colts, and head coach Bruce Arians said he doesn't know when Brown will be healthy enough to play again. Unfortunately, that's just the facts of life for Brown, whose sickle-cell trait makes it difficult for him to quickly recover from any soft-tissue injury. He was absent for most of training camp because of a quad injury. Without Brown and running back David Johnson, Larry Fitzgerald should be a target monster in Indy. If you're looking for a deep sleeper here, take a gander at deep-threat speedster J.J. Nelson.
Kevin White, Chicago Bears
It's as if White's body is telling him that he's not made to play in the NFL. He was placed on injured reserve Monday after breaking a shoulder blade in Week 1. It's not a foregone conclusion that his season is done, but it is another terrible bit of bad luck for White, who has played in five regular-season games since being drafted seventh overall in 2015. Kendall Wright looks to be the Bears' No. 1 wideout for now, yet he is only a WR4 in most leagues at the moment. Diminutive rookie running back Tarik Cohen could become more of a focal point given Chicago's thin receiving corps.
Terrance Williams, Dallas Cowboys
Williams was bothered by a sprained ankle Sunday night versus the Giants, but he was able to finish the victory and compile 68 yards on six catches. He missed practice Wednesday and Thursday, but his return to the field Friday means he will probably suit up against the Broncos. Healthy or not, Williams is not an advisable fantasy start against Denver's fierce secondary.
Michael Campanaro, Baltimore Ravens
Campanaro might have a weekly role in the Ravens' offense now that Danny Woodhead is on the shelf for a while. But first, he needs to stay on the field himself. The former seventh-rounder was added to the team's injury report Friday with a back ailment and is listed as questionable to face the Browns. Campanaro has played in just 12 games since becoming a pro in 2014 because of an assortment of injuries. If health ever stays on his side, he will be someone to watch in deep leagues.
Mike Williams, Los Angeles Chargers
Don't get too excited; Williams is still not expected to make his NFL debut until October. The good news, however, is that he practiced Friday. It was his first practice since sustaining a back injury on the first day of rookie minicamp four months ago. #Progress.
Josh Doctson, Washington Redskins
Once again, Doctson is being affected by hamstring problems. He sat out nine days of training camp last month because of it and was limited by it during the practice week. Head coach Jay Gruden called Doctson's absence Wednesday "precautionary," but he likely won't see a full allotment of snaps Sunday. Even if he plays against the Rams, Doctson is no better than the Redskins' fifth-best receiving target right now.
Markus Wheaton Chicago Bears
The Bears could really use Wheaton this week and they might get their wish. He went through a limited practice week and has a decent shot of playing this weekend after missing a chunk of time due to a broken finger. He is just a WR5 in fantasy at the moment, but there is certainly room for opportunity in Chicago's WR corps.
Josh Bellamy, Chicago Bears
Speaking of the Bears' receiving corps, Bellamy turned an ankle during Thursday's practice but should be active against the Buccaneers regardless. Bellamy, who caught three passes for 27 yards in Week 1, is officially listed as questionable.
Dontrelle Inman, Los Angeles Chargers
Inman was inactive for Week 1 because of a groin injury, but he logged three full practices this week and should be on the field against the Dolphins despite getting tagged as questionable. He won't be a fantasy factor until something happens to Keenan Allen and/or Tyrell Williams.
Chester Rogers, Indianapolis Colts
The Colts' No. 3 wide receiver, Rogers put in a full practice Friday after spending a couple of days nursing some hamstring pain. He might be out there against the Cardinals, but he won't be on the fantasy radar until Luck is back under center.
RUNNING BACKS
David Johnson, Arizona Cardinals
The biggest fantasy injury news of the year thus far: Johnson, a top-two pick in basically every draft this summer, will undergo wrist surgery this week and is expected to be sidelined for 2-3 months. Head coach Bruce Arians said Tuesday that the team hopes to have Johnson back on the field by Christmas. Yikes -- that's Week 16 or 17. In other words, Johnson probably won't be useful to most fantasy squads for the rest of the season. Arizona will "replace" Johnson by running out the quartet of Kerwynn Williams, Andre Ellington, the newly re-signed Chris Johnson and undrafted free agent rookie Elijhaa Penny. Williams is the best fantasy add of the bunch since he will start in a good matchup versus the Colts this weekend. However, this is going to be a committee backfield without question for at least a while. Thus, Williams is no better than a flex option in Week 2. Ellington, acting as the third-down back, is a person of interest in PPR formats.
LeSean McCoy, Buffalo Bills
Shady's owners probably lost their collective breath for a moment when they saw that McCoy was absent from Friday's practice. However, the Bills said it was just a day of rest for their workhorse, who has experienced some groin soreness. He's a locked-in RB1 versus the Panthers.
Jordan Howard, Chicago Bears
As if things weren't already bad enough for Howard's fantasy value, he is dealing with a shoulder injury right now and was limited during all three practices this week. He is expected to play but may not get a full workload. He is strictly an RB2 versus the Buccaneers. To wit, I have ranked Howard as the No. 18 RB for Week 2.
Thomas Rawls, Seattle Seahawks
Last week, Rawls practiced in full but was inactive against the Packers. This week, Rawls practiced in full but ... he will be available to face the 49ers. He was removed from Seattle's injury report Friday. The problem is the Seahawks are probably going to give each of their three other backs some run as well -- Eddie Lacy, C.J. Prosise and Chris Carson. Everyone here, including Carson, should be owned in most leagues, but I'd give this situation a week or two to clear up. If Lacy doesn't improve from his 3-yard outing in Week 1, Rawls might have the inside track on the early-down work here. It's too early to tell right now.
Danny Woodhead, Baltimore Ravens
The Ravens placed Woodhead on injured reserve Thursday after he strained his left hamstring early on in the Ravens' Week 1 win. It's a shame because Woodhead caught three passes for 33 yards on Baltimore's first drive of the game, the only drive in which Woodhead was available. Whenever he stays healthy, he is a lethal receiving weapon out of the backfield. But staying healthy has been a tough task for Woodhead as he has suffered major early-season injuries in three of the last four seasons now. Javorius "Buck" Allen and Terrance West split the carries without Woodhead around, but it was Allen, Woodhead's true replacement, who paced the backfield with 33 snaps. He's another popular pickup this week and looks to be flex-worthy versus the Browns.
T.J. Yeldon, Jacksonville Jaguars
Yeldon should make his season debut Sunday against the Titans after missing Week 1's win because of a hamstring injury. The Alabama alum participated fully in practice all week. However, he probably won't see more than a handful of touches behind Fournette. He may still need to jump over Chris Ivory on the depth chart, too.
Devontae Booker, Denver Broncos
Booker has begun practicing after fracturing his wrist in July. He has been ruled out for Week 2 but could make his 2017 debut within a couple of weeks. The Broncos' backfield belongs to C.J. Anderson until further notice.
Benny Cunningham, Chicago Bears
Cunningham came out of Week 1 with a high-ankle sprain, so don't expect to see him around for at least a few weeks. However, with the emergence of Tarik Cohen, whom I have now mentioned three times, directly or indirectly, in this column, Cunningham frankly isn't needed right now.
Donnel Pumphrey, Philadelphia Eagles
This fourth-round rookie suffered a torn hamstring this week and has been sent to injured reserve. A healthy scratch in Week 1, Pumphrey's season is probably over.
TIGHT ENDS
Jordan Reed, Washington Redskins
Just hours before the Redskins' Week 1 kickoff, it was reported that Reed has a fractured big toe. It didn't seem to hamper him too much versus the Eagles, and Reed isn't on Washington's Week 2 injury report. But this being Jordan Reed, you can expect his name to be in this column quite often. Our Daniel Brown him ranked as his No. 9 TE for this week.
Charles Clay, Buffalo Bills
Coming off an 11-point fantasy day in standard leagues, Clay was limited during Wednesday's practice due to a shoulder injury. But after being upgraded to full practice on Thursday and Friday, he should be fine for Sunday's meeting with the Panthers and is an intriguing sleeper after seeing nine targets in the season opener.
Jermaine Gresham, Arizona Cardinals
Gresham has been labeled as a game-time decision, but after sitting out of practice all week due to rib pain, it seems unlikely that he will be active against the Colts. Instead of concerning yourself with whom Gresham's backup is, know that you can find better options elsewhere.
Vance McDonald, Pittsburgh Steelers
Good news for those who want to ride the Jesse James wave after his two-touchdown performance in Week 1: McDonald didn't practice on Thursday or Friday because of a back injury. He played just 19 snaps in Week 1, failing to register a catch. Odds are he will not suit up for Pittsburgh's home opener versus the Vikings. James did crack Daniel Brown's top-20 tight end rankings this week.
KICKERS
Sebastian Janikowski, Oakland Raiders
I don't usually cover kickers here, but a couple of teams have had to make changes at that position due to injuries, so let's cover those quickly. Janikowski, the Raiders' longest-tenured player, was placed on injured reserve on Week 1 eve because of a herniated disc in his back. He won't need surgery but will miss at least eight weeks. Oakland replaced him with the luxuriously named Giorgio Tavecchio. All he did versus the Titans was nail each of his four field goal attempts, including two from 50-plus yards. Pick him up if you were a Seabass owner. The Raiders should boast a high-scoring offense this year.
Caleb Sturgis, Philadelphia Eagles
A left quad strain suffered in Week 1 has landed Sturgis on IR. The Eagles have replaced him with Jake Elliott, who was a fifth-round pick of the Bengals this year.
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Other injured players who are fully expected to play in Week 2 include: RB Jay Ajayi, Miami Dolphins; WR Amari Cooper, Oakland Raiders; WR Jamison Crowder, Washington Redskins; TE George Kittle, San Francisco 49ers.
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