Also look at these other Week 2 rankings: QBs WRs TEs
Updated as of Sept. 16.
| Rank | Player | Team | Opp |
| 1 | Le'Veon Bell | PIT | MIN |
| 2 | Ezekiel Elliott | DAL | @DEN |
| 3 | Melvin Gordon | LAC | MIA |
| 4 | LeSean McCoy | BUF | @CAR |
| 5 | Devonta Freeman | ATL | GB |
| 6 | Jay Ajayi | MIA | @LAC |
| 7 | Marshawn Lynch | OAK | NYJ |
| 8 | Leonard Fournette | JAC | TEN |
| 9 | Kareem Hunt | KC | PHI |
| 10 | Ty Montgomery | GB | @ATL |
| 11 | Dalvin Cook | MIN | @PIT |
| 12 | Todd Gurley | LAR | WAS |
| 13 | DeMarco Murray | TEN | @JAC |
| 14 | Mike Gillislee | NE | @NO |
| 15 | Terrance West | BAL | CLE |
| 16 | C.J. Anderson | DEN | DAL |
| 17 | Jordan Howard | CHI | @TB |
| 18 | Christian McCaffrey | CAR | BUF |
| 19 | Mark Ingram | NO | NE |
| 20 | Tevin Coleman | ATL | GB |
Get In-Season Analyzer for lineup, waiver and trade help with blended projections from Pro Football Focus, 4for4, Fantasy Gurus, NumberFire and Fantasy Sharks.
| Rank | Player | Team | Opp |
| 21 | Jonathan Stewart | CAR | BUF |
| 22 | Jacquizz Rodgers | TB | CHI |
| 23 | Carlos Hyde | SF | @SEA |
| 24 | Isaiah Crowell | CLE | @BAL |
| 25 | James White | NE | @NO |
| 26 | Tarik Cohen | CHI | @TB |
| 27 | Ameer Abdullah | DET | @NYG |
| 28 | Rob Kelley | WAS | @LAR |
| 29 | Frank Gore | IND | ARI |
| 30 | Bilal Powell | NYJ | @OAK |
| 31 | Javorius Allen | BAL | CLE |
| 32 | Kerwynn Williams | ARI | @IND |
| 33 | LeGarrette Blount | PHI | @KC |
| 34 | Paul Perkins | NYG | DET |
| 35 | Alvin Kamara | NO | NE |
| 36 | Thomas Rawls | SEA | SF |
| 37 | Darren Sproles | PHI | @KC |
| 38 | Chris Carson | SEA | SF |
| 39 | Theo Riddick | DET | @NYG |
| 40 | Chris Thompson | WAS | @LAR |
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