All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 10:08 AM ET.
| Rank | Player | Match |
| 1 | Jahmyr Gibbs | Det vs NYJ |
| 2 | Christian McCaffrey | SF vs Ari |
| 3 | Jonathan Taylor | Ind vs Hou |
| 4 | Kenneth Walker III | KC @ Mia |
| 5 | Derrick Henry | Bal @ Dal |
| 6 | James Cook | Buf vs LAC |
| 7 | Chase Brown | Cin @ Pit |
| 8 | Ashton Jeanty | LV @ NO |
| 9 | De'Von Achane | Mia vs KC |
| 10 | Saquon Barkley | Phi @ Chi |
| 11 | Javonte Williams | Dal vs Bal |
| 12 | Breece Hall | NYJ @ Det |
| 13 | Jaylen Warren (Q) | Pit vs Cin |
| 14 | Omarion Hampton | LAC @ Buf |
| 15 | Quinshon Judkins | Cle vs Car |
| 16 | Cam Skattebo | NYG vs Ten |
| 17 | Jeremiyah Love | Ari @ SF |
| 18 | Chuba Hubbard | Car @ Cle |
| 19 | David Montgomery | Hou @ Ind |
| 20 | Aaron Jones | Min @ TB |
| Rank | Player | Match |
| 21 | Kyren Williams | LAR @ Den |
| 22 | D'Andre Swift | Chi vs Phi |
| 23 | Bucky Irving | TB vs Min |
| 24 | Jadarian Price | Sea @ Wsh |
| 25 | Travis Etienne | NO vs LV |
| 26 | Tony Pollard | Ten @ NYG |
| 27 | Rhamondre Stevenson | NE @ Jax |
| 28 | Bhayshul Tuten | Jax vs NE |
| 29 | J.K. Dobbins | Den vs LAR |
| 30 | Blake Corum | LAR @ Den |
| 31 | RJ Harvey | Den vs LAR |
| 32 | TreVeyon Henderson | NE @ Jax |
| 33 | Jacory Croskey-Merritt | Wsh vs Sea |
| 34 | Kyle Monangai | Chi vs Phi |
| 35 | Woody Marks | Hou @ Ind |
| 36 | Rico Dowdle (Out) | Pit vs Cin |
| 37 | Tyjae Spears (Q) | Ten @ NYG |
| 38 | Kenneth Gainwell | TB vs Min |
| 39 | Kaelon Black | SF vs Ari |
| 40 | Tyler Allgeier | Ari @ SF |
