All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 6:22 PM ET.
| Rank | Player | Match |
| 1 | Jonathan Taylor | Ind @ Jax |
| 2 | Jahmyr Gibbs | Det vs Dal |
| 3 | De'Von Achane | Mia @ NYJ |
| 4 | Josh Jacobs | GB vs Chi |
| 5 | James Cook | Buf vs Cin |
| 6 | Bijan Robinson | Atl vs Sea |
| 7 | Breece Hall | NYJ vs Mia |
| 8 | Chase Brown | Cin @ Buf |
| 9 | Kyren Williams | LAR @ Ari |
| 10 | Derrick Henry | Bal vs Pit |
| 11 | Quinshon Judkins | Cle vs Ten |
| 12 | Saquon Barkley | Phi @ LAC |
| 13 | Bucky Irving | TB vs NO |
| 14 | Ashton Jeanty | LV vs Den |
| 15 | Travis Etienne | Jax vs Ind |
| 16 | Javonte Williams | Dal @ Det |
| 17 | RJ Harvey | Den @ LV |
| 18 | Kenneth Walker III | Sea @ Atl |
| 19 | Devin Neal | NO @ TB |
| 20 | Woody Marks | Hou @ KC |
| Rank | Player | Match |
| 21 | Jaylen Warren | Pit @ Bal |
| 22 | Omarion Hampton | LAC vs Phi |
| 23 | Bam Knight | Ari vs LAR |
| 24 | David Montgomery | Det vs Dal |
| 25 | D'Andre Swift | Chi @ GB |
| 26 | Jordan Mason | Min vs Wsh |
| 27 | Zach Charbonnet | Sea @ Atl |
| 28 | Kareem Hunt | KC vs Hou |
| 29 | Kenneth Gainwell | Pit @ Bal |
| 30 | Tyjae Spears | Ten @ Cle |
| 31 | Tony Pollard | Ten @ Cle |
| 32 | Chris Rodriguez Jr. | Wsh @ Min |
| 33 | Kyle Monangai (Q) | Chi @ GB |
| 34 | Kimani Vidal | LAC vs Phi |
| 35 | Bhayshul Tuten | Jax vs Ind |
| 36 | Isiah Pacheco | KC vs Hou |
| 37 | Emanuel Wilson | GB vs Chi |
| 38 | Nick Chubb | Hou @ KC |
| 39 | Blake Corum | LAR @ Ari |
| 40 | Jaleel McLaughlin | Den @ LV |
