All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Wed 1:38 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ Cle |
| 2 | De'Von Achane | Mia vs NO |
| 3 | Bijan Robinson | Atl @ NYJ |
| 4 | Jonathan Taylor | Ind vs Hou |
| 5 | Jaxon Smith-Njigba | Sea vs Min |
| 6 | Jahmyr Gibbs | Det vs GB |
| 7 | Amon-Ra St. Brown | Det vs GB |
| 8 | Saquon Barkley (Q) | Phi vs Chi |
| 9 | Puka Nacua | LAR @ Car |
| 10 | Ja'Marr Chase | Cin @ Bal |
| 11 | Derrick Henry | Bal vs Cin |
| 12 | James Cook | Buf @ Pit |
| 13 | Kyren Williams | LAR @ Car |
| 14 | Rashee Rice | KC @ Dal |
| 15 | Josh Jacobs (Q) | GB @ Det |
| 16 | CeeDee Lamb | Dal vs KC |
| 17 | Breece Hall | NYJ vs Atl |
| 18 | Davante Adams | LAR @ Car |
| 19 | George Pickens (Q) | Dal vs KC |
| 20 | TreVeyon Henderson | NE vs NYG |
| 21 | Ashton Jeanty (Q) | LV @ LAC |
| 22 | Emeka Egbuka | TB vs Ari |
| 23 | Travis Etienne | Jax @ Ten |
| 24 | Trey McBride | Ari @ TB |
| 25 | Zay Flowers | Bal vs Cin |
| 26 | Rico Dowdle | Car vs LAR |
| 27 | Chase Brown | Cin @ Bal |
| 28 | Devin Neal | NO @ Mia |
| 29 | A.J. Brown | Phi vs Chi |
| 30 | Quinshon Judkins | Cle vs SF |
| 31 | Nico Collins | Hou @ Ind |
| 32 | Chris Olave | NO @ Mia |
| 33 | Javonte Williams | Dal vs KC |
| 34 | Kenneth Walker III | Sea vs Min |
| 35 | RJ Harvey | Den @ Wsh |
| Rank | Player | Match |
| 36 | Woody Marks | Hou @ Ind |
| 37 | Bucky Irving (Q) | TB vs Ari |
| 38 | Brock Bowers | LV @ LAC |
| 39 | DeVonta Smith (Q) | Phi vs Chi |
| 40 | Ladd McConkey | LAC vs LV |
| 41 | Jaylen Warren | Pit vs Buf |
| 42 | Justin Jefferson | Min @ Sea |
| 43 | Jaylen Waddle | Mia vs NO |
| 44 | Tetairoa McMillan | Car vs LAR |
| 45 | Tyrone Tracy Jr. | NYG @ NE |
| 46 | Stefon Diggs | NE vs NYG |
| 47 | Tyler Warren | Ind vs Hou |
| 48 | George Kittle | SF @ Cle |
| 49 | Courtland Sutton | Den @ Wsh |
| 50 | Jameson Williams | Det vs GB |
| 51 | Travis Kelce | KC @ Dal |
| 52 | Troy Franklin | Den @ Wsh |
| 53 | Wan'Dale Robinson | NYG @ NE |
| 54 | D.K. Metcalf (Q) | Pit vs Buf |
| 55 | D'Andre Swift | Chi @ Phi |
| 56 | Michael Pittman Jr. | Ind vs Hou |
| 57 | David Montgomery | Det vs GB |
| 58 | Mark Andrews | Bal vs Cin |
| 59 | Quentin Johnston | LAC vs LV |
| 60 | Zach Charbonnet | Sea vs Min |
| 61 | Romeo Doubs | GB @ Det |
| 62 | Jakobi Meyers | Jax @ Ten |
| 63 | Xavier Worthy | KC @ Dal |
| 64 | Khalil Shakir | Buf @ Pit |
| 65 | Michael Wilson | Ari @ TB |
| 66 | Aaron Jones | Min @ Sea |
| 67 | Rome Odunze | Chi @ Phi |
| 68 | Omarion Hampton (IR) | LAC vs LV |
| 69 | Kareem Hunt | KC @ Dal |
| 70 | Tony Pollard | Ten vs Jax |
