All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 10:35 AM ET.
| Rank | Player | Match |
| 1 | Jonathan Taylor | Ind vs Ten |
| 2 | Bijan Robinson | Atl vs Mia |
| 3 | Christian McCaffrey | SF @ Hou |
| 4 | James Cook | Buf @ Car |
| 5 | De'Von Achane | Mia @ Atl |
| 6 | Saquon Barkley | Phi vs NYG |
| 7 | Josh Jacobs | GB @ Pit |
| 8 | Derrick Henry | Bal vs Chi |
| 9 | Rachaad White | TB @ NO |
| 10 | Breece Hall | NYJ @ Cin |
| 11 | Quinshon Judkins | Cle @ NE |
| 12 | Alvin Kamara | NO vs TB |
| 13 | Javonte Williams | Dal @ Den |
| 14 | Chase Brown | Cin vs NYJ |
| 15 | J.K. Dobbins | Den vs Dal |
| 16 | D'Andre Swift | Chi @ Bal |
| 17 | Cam Skattebo | NYG @ Phi |
| 18 | Jaylen Warren | Pit vs GB |
| 19 | Rico Dowdle | Car vs Buf |
| 20 | Rhamondre Stevenson | NE vs Cle |
| Rank | Player | Match |
| 21 | Woody Marks | Hou vs SF |
| 22 | Chuba Hubbard | Car vs Buf |
| 23 | Jacory Croskey-Merritt | Wsh @ KC |
| 24 | Tony Pollard | Ten @ Ind |
| 25 | Isiah Pacheco | KC vs Wsh |
| 26 | Kareem Hunt (Q) | KC vs Wsh |
| 27 | Nick Chubb | Hou vs SF |
| 28 | Kenneth Gainwell | Pit vs GB |
| 29 | Tyler Allgeier | Atl vs Mia |
| 30 | Justice Hill | Bal vs Chi |
| 31 | RJ Harvey | Den vs Dal |
| 32 | Tyjae Spears | Ten @ Ind |
| 33 | TreVeyon Henderson | NE vs Cle |
| 34 | Tyrone Tracy Jr. | NYG @ Phi |
| 35 | Isaiah Davis | NYJ @ Cin |
| 36 | Samaje Perine | Cin vs NYJ |
| 37 | Kyle Monangai | Chi @ Bal |
| 38 | Jeremy McNichols | Wsh @ KC |
| 39 | Sean Tucker | TB @ NO |
| 40 | Ollie Gordon | Mia @ Atl |
