All position ranks are: QB WR TE FLEX DEF
These rankings were updated as of Thu 8:25 AM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Bal vs Cle |
| 2 | Jahmyr Gibbs | Det vs Chi |
| 3 | Josh Jacobs | GB vs Wsh |
| 4 | De'Von Achane | Mia vs NE |
| 5 | Saquon Barkley | Phi @ KC |
| 6 | Christian McCaffrey | SF @ NO |
| 7 | Chase Brown | Cin vs Jax |
| 8 | Kyren Williams | LAR @ Ten |
| 9 | Bijan Robinson | Atl @ Min |
| 10 | James Conner | Ari vs Car |
| 11 | Jonathan Taylor | Ind vs Den |
| 12 | Chuba Hubbard | Car @ Ari |
| 13 | Ashton Jeanty | LV vs LAC |
| 14 | James Cook (Q) | Buf @ NYJ |
| 15 | Bucky Irving | TB @ Hou |
| 16 | Tony Pollard | Ten vs LAR |
| 17 | Breece Hall | NYJ vs Buf |
| 18 | Javonte Williams | Dal vs NYG |
| 19 | Alvin Kamara | NO vs SF |
| 20 | Omarion Hampton | LAC @ LV |
| Rank | Player | Match |
| 21 | D'Andre Swift | Chi @ Det |
| 22 | Tyrone Tracy Jr. | NYG @ Dal |
| 23 | Aaron Jones | Min vs Atl |
| 24 | David Montgomery | Det vs Chi |
| 25 | Travis Etienne | Jax @ Cin |
| 26 | Jaylen Warren | Pit vs Sea |
| 27 | Zach Charbonnet | Sea @ Pit |
| 28 | Jordan Mason | Min vs Atl |
| 29 | J.K. Dobbins | Den @ Ind |
| 30 | Kenneth Walker III | Sea @ Pit |
| 31 | Nick Chubb | Hou vs TB |
| 32 | Jacory Croskey-Merritt | Wsh @ GB |
| 33 | TreVeyon Henderson | NE @ Mia |
| 34 | Dylan Sampson | Cle @ Bal |
| 35 | Austin Ekeler | Wsh @ GB |
| 36 | RJ Harvey | Den @ Ind |
| 37 | Isiah Pacheco | KC vs Phi |
| 38 | Rhamondre Stevenson | NE @ Mia |
| 39 | Trey Benson | Ari vs Car |
| 40 | Kareem Hunt | KC vs Phi |
