These rankings were updated as of Thu 12:38 PM ET.
| Rank | Player | Match |
| 1 | Saquon Barkley | Phi vs Dal |
| 2 | Bijan Robinson | Atl vs TB |
| 3 | Derrick Henry | Bal @ Buf |
| 4 | Christian McCaffrey | SF @ Sea |
| 5 | De'Von Achane (Q) | Mia @ Ind |
| 6 | Jahmyr Gibbs | Det @ GB |
| 7 | Jonathan Taylor | Ind vs Mia |
| 8 | Josh Jacobs | GB vs Det |
| 9 | Chase Brown | Cin @ Cle |
| 10 | Bucky Irving | TB @ Atl |
| 11 | Kyren Williams | LAR vs Hou |
| 12 | Ashton Jeanty | LV @ NE |
| 13 | James Conner | Ari @ NO |
| 14 | Alvin Kamara | NO vs Ari |
| 15 | Chuba Hubbard | Car @ Jax |
| 16 | James Cook | Buf vs Bal |
| 17 | Kenneth Walker III | Sea vs SF |
| 18 | Tony Pollard | Ten @ Den |
| 19 | Omarion Hampton | LAC vs KC |
| 20 | TreVeyon Henderson | NE vs LV |
| Rank | Player | Match |
| 21 | Breece Hall | NYJ vs Pit |
| 22 | Jerome Ford | Cle vs Cin |
| 23 | Aaron Jones | Min @ Chi |
| 24 | Tyrone Tracy Jr. | NYG @ Wsh |
| 25 | Jaylen Warren | Pit @ NYJ |
| 26 | D'Andre Swift | Chi vs Min |
| 27 | Isiah Pacheco | KC @ LAC |
| 28 | RJ Harvey | Den vs Ten |
| 29 | David Montgomery | Det @ GB |
| 30 | Austin Ekeler | Wsh vs NYG |
| 31 | Travis Etienne | Jax vs Car |
| 32 | J.K. Dobbins | Den vs Ten |
| 33 | Zach Charbonnet | Sea vs SF |
| 34 | Jacory Croskey-Merritt | Wsh vs NYG |
| 35 | Dylan Sampson | Cle vs Cin |
| 36 | Tank Bigsby | Jax vs Car |
| 37 | Jordan Mason | Min @ Chi |
| 38 | Javonte Williams | Dal @ Phi |
| 39 | Rhamondre Stevenson | NE vs LV |
| 40 | Nick Chubb | Hou @ LAR |
