All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Wed 8:54 AM ET.
| Rank | Player | Match |
| 1 | Saquon Barkley | Phi vs Dal |
| 2 | Jahmyr Gibbs | Det @ SF |
| 3 | De'Von Achane | Mia @ Cle |
| 4 | Chase Brown | Cin vs Den |
| 5 | Bijan Robinson | Atl @ Wsh |
| 6 | Kyren Williams | LAR vs Ari |
| 7 | Jonathan Taylor | Ind @ NYG |
| 8 | Josh Jacobs | GB @ Min |
| 9 | Chuba Hubbard | Car @ TB |
| 10 | Aaron Jones | Min vs GB |
| 11 | Bucky Irving | TB vs Car |
| 12 | Breece Hall | NYJ @ Buf |
| 13 | James Cook | Buf vs NYJ |
| 14 | Isaac Guerendo (Q) | SF vs Det |
| 15 | Rico Dowdle | Dal @ Phi |
| 16 | D'Andre Swift | Chi vs Sea |
| 17 | Brian Robinson | Wsh vs Atl |
| 18 | Zach Charbonnet (P) | Sea @ Chi |
| 19 | Tony Pollard | Ten @ Jax |
| 20 | Jerome Ford | Cle vs Mia |
| Rank | Player | Match |
| 21 | Tyrone Tracy Jr. | NYG vs Ind |
| 22 | Rhamondre Stevenson | NE vs LAC |
| 23 | Rachaad White | TB vs Car |
| 24 | James Conner (Q) | Ari @ LAR |
| 25 | Alexander Mattison | LV @ NO |
| 26 | Travis Etienne | Jax vs Ten |
| 27 | Kendre Miller | NO vs LV |
| 28 | Kenneth Walker III (Q) | Sea @ Chi |
| 29 | Tank Bigsby | Jax vs Ten |
| 30 | Javonte Williams | Den @ Cin |
| 31 | Gus Edwards (Q) | LAC @ NE |
| 32 | Tyjae Spears | Ten @ Jax |
| 33 | Ameer Abdullah | LV @ NO |
| 34 | Alvin Kamara (Q) | NO vs LV |
| 35 | Raheem Mostert | Mia @ Cle |
| 36 | Antonio Gibson | NE vs LAC |
| 37 | Tyler Allgeier | Atl @ Wsh |
| 38 | Devin Singletary | NYG vs Ind |
| 39 | Audric Estime | Den @ Cin |
| 40 | Roschon Johnson | Chi vs Sea |
