All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 8:10 AM ET.
| Rank | Player | Match |
| 1 | Jahmyr Gibbs | Det @ Chi |
| 2 | Bijan Robinson | Atl vs NYG |
| 3 | Saquon Barkley | Phi @ Wsh |
| 4 | Chase Brown | Cin vs Cle |
| 5 | De'Von Achane | Mia vs SF |
| 6 | James Conner | Ari @ Car |
| 7 | Joe Mixon | Hou @ KC |
| 8 | Derrick Henry | Bal vs Pit |
| 9 | Kyren Williams | LAR @ NYJ |
| 10 | Chuba Hubbard | Car vs Ari |
| 11 | Jonathan Taylor | Ind vs Ten |
| 12 | Aaron Jones | Min @ Sea |
| 13 | Bucky Irving | TB @ Dal |
| 14 | Breece Hall | NYJ vs LAR |
| 15 | Rico Dowdle | Dal vs TB |
| 16 | James Cook | Buf vs NE |
| 17 | Tony Pollard (Q) | Ten @ Ind |
| 18 | Jerome Ford | Cle @ Cin |
| 19 | D'Andre Swift | Chi vs Det |
| 20 | Kenneth Walker III | Sea vs Min |
| Rank | Player | Match |
| 21 | Tyrone Tracy Jr. (Q) | NYG @ Atl |
| 22 | Brian Robinson | Wsh vs Phi |
| 23 | Rhamondre Stevenson | NE @ Buf |
| 24 | Rachaad White | TB @ Dal |
| 25 | Isiah Pacheco | KC vs Hou |
| 26 | Najee Harris | Pit vs KC |
| 27 | Travis Etienne | Jax @ LV |
| 28 | Alexander Mattison | LV vs Jax |
| 29 | Zach Charbonnet | Sea vs Min |
| 30 | Tank Bigsby | Jax @ LV |
| 31 | Tyjae Spears | Ten @ Ind |
| 32 | Jaylen Warren | Pit vs KC |
| 33 | Ameer Abdullah | LV vs Jax |
| 34 | Patrick Taylor | SF @ Mia |
| 35 | Kareem Hunt | KC vs Hou |
| 36 | Justice Hill | Bal vs Pit |
| 37 | Tyler Allgeier | Atl vs NYG |
| 38 | Isaac Guerendo (Out) | SF @ Mia |
| 39 | Devin Singletary | NYG @ Atl |
| 40 | Ray Davis | Buf vs NE |
