All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 7:35 AM ET.
| Rank | Player | Match |
| 1 | Bijan Robinson | Atl @ NO |
| 2 | Alvin Kamara | NO vs Atl |
| 3 | Saquon Barkley | Phi vs Wsh |
| 4 | Christian McCaffrey (Q) | SF @ TB |
| 5 | De'Von Achane | Mia @ LAR |
| 6 | Kyren Williams | LAR vs Mia |
| 7 | Joe Mixon | Hou vs Det |
| 8 | Jonathan Taylor | Ind vs Buf |
| 9 | Breece Hall | NYJ @ Ari |
| 10 | Aaron Jones | Min @ Jax |
| 11 | J.K. Dobbins | LAC vs Ten |
| 12 | Jahmyr Gibbs | Det @ Hou |
| 13 | D'Andre Swift | Chi vs NE |
| 14 | Kareem Hunt | KC vs Den |
| 15 | James Conner | Ari vs NYJ |
| 16 | Tyrone Tracy Jr. | NYG @ Car |
| 17 | James Cook | Buf @ Ind |
| 18 | Tony Pollard | Ten @ LAC |
| 19 | David Montgomery | Det @ Hou |
| 20 | Chuba Hubbard | Car vs NYG |
| Rank | Player | Match |
| 21 | Najee Harris | Pit @ Wsh |
| 22 | Rhamondre Stevenson | NE @ Chi |
| 23 | Rico Dowdle | Dal vs Phi |
| 24 | Austin Ekeler | Wsh vs Pit |
| 25 | Rachaad White | TB vs SF |
| 26 | Javonte Williams | Den @ KC |
| 27 | Bucky Irving | TB vs SF |
| 28 | Raheem Mostert | Mia @ LAR |
| 29 | Tank Bigsby | Jax vs Min |
| 30 | Jaylen Warren | Pit @ Wsh |
| 31 | Tyler Allgeier | Atl @ NO |
| 32 | Travis Etienne | Jax vs Min |
| 33 | Jonathon Brooks (Q) | Car vs NYG |
| 34 | Tyjae Spears | Ten @ LAC |
| 35 | Ray Davis | Buf @ Ind |
| 36 | Devin Singletary | NYG @ Car |
| 37 | Braelon Allen | NYJ @ Ari |
| 38 | Jordan Mason | SF @ TB |
| 39 | Roschon Johnson | Chi vs NE |
| 40 | Jeremy McNichols | Wsh vs Pit |
