All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 9:31 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey (Q) | SF vs NYJ |
| 2 | Tyreek Hill | Mia vs Jax |
| 3 | Bijan Robinson | Atl vs Pit |
| 4 | Amon-Ra St. Brown | Det vs LAR |
| 5 | Breece Hall | NYJ @ SF |
| 6 | Justin Jefferson | Min @ NYG |
| 7 | Jonathan Taylor | Ind vs Hou |
| 8 | Puka Nacua | LAR @ Det |
| 9 | Jahmyr Gibbs | Det vs LAR |
| 10 | Alvin Kamara | NO vs Car |
| 11 | Ja'Marr Chase (Q) | Cin vs NE |
| 12 | Cooper Kupp | LAR @ Det |
| 13 | Joe Mixon | Hou @ Ind |
| 14 | De'Von Achane | Mia vs Jax |
| 15 | Kyren Williams | LAR @ Det |
| 16 | Nico Collins | Hou @ Ind |
| 17 | Rachaad White | TB vs Wsh |
| 18 | Mike Evans | TB vs Wsh |
| 19 | Kenneth Walker III | Sea vs Den |
| 20 | Travis Etienne Jr. | Jax @ Mia |
| 21 | Drake London | Atl vs Pit |
| 22 | Garrett Wilson | NYJ @ SF |
| 23 | Jaylen Waddle | Mia vs Jax |
| 24 | James Cook | Buf vs Ari |
| 25 | Davante Adams | LV @ LAC |
| 26 | Chris Olave | NO vs Car |
| 27 | Marvin Harrison Jr. | Ari @ Buf |
| 28 | Sam LaPorta | Det vs LAR |
| 29 | Stefon Diggs | Hou @ Ind |
| 30 | CeeDee Lamb (Out) | Dal @ Cle |
| 31 | Aaron Jones | Min @ NYG |
| 32 | DK Metcalf | Sea vs Den |
| 33 | Michael Pittman Jr. | Ind vs Hou |
| 34 | Rhamondre Stevenson | NE @ Cin |
| 35 | James Conner | Ari @ Buf |
| Rank | Player | Match |
| 36 | Amari Cooper | Cle vs Dal |
| 37 | Tank Dell | Hou @ Ind |
| 38 | Jerome Ford | Cle vs Dal |
| 39 | Christian Kirk | Jax @ Mia |
| 40 | DJ Moore | Chi vs Ten |
| 41 | Deebo Samuel Sr. | SF vs NYJ |
| 42 | Malik Nabers | NYG vs Min |
| 43 | Chris Godwin | TB vs Wsh |
| 44 | David Montgomery | Det vs LAR |
| 45 | Brandon Aiyuk | SF vs NYJ |
| 46 | George Pickens | Pit @ Atl |
| 47 | Dalton Kincaid | Buf vs Ari |
| 48 | Terry McLaurin | Wsh @ TB |
| 49 | Javonte Williams | Den @ Sea |
| 50 | Keenan Allen (Q) | Chi vs Ten |
| 51 | Chuba Hubbard | Car @ NO |
| 52 | Raheem Mostert | Mia vs Jax |
| 53 | Devin Singletary | NYG vs Min |
| 54 | Najee Harris | Pit @ Atl |
| 55 | Calvin Ridley | Ten @ Chi |
| 56 | Kyle Pitts | Atl vs Pit |
| 57 | Joshua Palmer | LAC vs LV |
| 58 | Evan Engram | Jax @ Mia |
| 59 | Zamir White | LV @ LAC |
| 60 | D'Andre Swift | Chi vs Ten |
| 61 | Tony Pollard | Ten @ Chi |
| 62 | Trey McBride | Ari @ Buf |
| 63 | Jaxon Smith-Njigba | Sea vs Den |
| 64 | Diontae Johnson | Car @ NO |
| 65 | Brian Thomas Jr. | Jax @ Mia |
| 66 | DeAndre Hopkins (Q) | Ten @ Chi |
| 67 | Courtland Sutton | Den @ Sea |
| 68 | George Kittle | SF vs NYJ |
| 69 | Tyler Lockett (Q) | Sea vs Den |
| 70 | Ladd McConkey | LAC vs LV |
