All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 7:05 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ Phi |
| 2 | Alvin Kamara | NO vs Det |
| 3 | Travis Etienne | Jax vs Cin |
| 4 | Kyren Williams | LAR vs Cle |
| 5 | Austin Ekeler | LAC @ NE |
| 6 | Rachaad White | TB vs Car |
| 7 | Tony Pollard | Dal vs Sea |
| 8 | Derrick Henry | Ten vs Ind |
| 9 | Isiah Pacheco | KC @ GB |
| 10 | Jahmyr Gibbs | Det @ NO |
| 11 | Bijan Robinson | Atl @ NYJ |
| 12 | Breece Hall (GTD) | NYJ vs Atl |
| 13 | Zack Moss | Ind @ Ten |
| 14 | Raheem Mostert (GTD) | Mia @ Wsh |
| 15 | Rhamondre Stevenson | NE vs LAC |
| 16 | D'Andre Swift (GTD) | Phi vs SF |
| 17 | Jaylen Warren | Pit vs Ari |
| 18 | Javonte Williams | Den @ Hou |
| 19 | David Montgomery (GTD) | Det @ NO |
| 20 | Joe Mixon | Cin @ Jax |
| Rank | Player | Match |
| 21 | Zach Charbonnet | Sea @ Dal |
| 22 | Brian Robinson Jr. | Wsh vs Mia |
| 23 | Najee Harris | Pit vs Ari |
| 24 | Jerome Ford | Cle @ LAR |
| 25 | Devin Singletary | Hou vs Den |
| 26 | James Conner | Ari @ Pit |
| 27 | A.J. Dillon (GTD) | GB vs KC |
| 28 | De'Von Achane (GTD) | Mia @ Wsh |
| 29 | Chuba Hubbard | Car @ TB |
| 30 | Kareem Hunt (Q) | Cle @ LAR |
| 31 | Aaron Jones (GTD) | GB vs KC |
| 32 | Ezekiel Elliott (GTD) | NE vs LAC |
| 33 | Antonio Gibson | Wsh vs Mia |
| 34 | Tyjae Spears | Ten vs Ind |
| 35 | Miles Sanders | Car @ TB |
| 36 | Tyler Allgeier | Atl @ NYJ |
| 37 | Samaje Perine | Den @ Hou |
| 38 | Dameon Pierce | Hou vs Den |
| 39 | Khalan Laborn | SF @ Phi |
| 40 | Rico Dowdle | Dal vs Sea |
