All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 1:39 PM ET.
| Rank | Player | Match |
| 1 | Alvin Kamara | NO vs Chi |
| 2 | Saquon Barkley (GTD) | NYG @ LV |
| 3 | Nick Chubb | Cle vs Ari |
| 4 | Austin Ekeler | LAC @ NYJ |
| 5 | Josh Jacobs | LV vs NYG |
| 6 | Breece Hall | NYJ vs LAC |
| 7 | Derrick Henry | Ten @ Pit |
| 8 | Tony Pollard | Dal @ Phi |
| 9 | Joe Mixon (GTD) | Cin vs Buf |
| 10 | Bijan Robinson | Atl vs Min |
| 11 | Jonathan Taylor | Ind @ Car |
| 12 | Raheem Mostert (GTD) | Mia @ KC |
| 13 | J.K. Dobbins | Bal vs Sea |
| 14 | D'Andre Swift | Phi vs Dal |
| 15 | Isiah Pacheco | KC vs Mia |
| 16 | Kenneth Walker III | Sea @ Bal |
| 17 | Rachaad White | TB @ Hou |
| 18 | Aaron Jones | GB vs LAR |
| 19 | Rhamondre Stevenson | NE vs Wsh |
| 20 | James Cook | Buf @ Cin |
| Rank | Player | Match |
| 21 | Darrell Henderson Jr. | LAR @ GB |
| 22 | Najee Harris | Pit vs Ten |
| 23 | Gus Edwards (GTD) | Bal vs Sea |
| 24 | Brian Robinson Jr. | Wsh @ NE |
| 25 | Emari Demercado (GTD) | Ari @ Cle |
| 26 | Zack Moss | Ind @ Car |
| 27 | Chuba Hubbard | Car vs Ind |
| 28 | Alexander Mattison | Min @ Atl |
| 29 | Dameon Pierce (GTD) | Hou vs TB |
| 30 | Kareem Hunt | Cle vs Ari |
| 31 | Jerome Ford (GTD) | Cle vs Ari |
| 32 | Jaylen Warren | Pit vs Ten |
| 33 | A.J. Dillon | GB vs LAR |
| 34 | D'Onta Foreman | Chi @ NO |
| 35 | Tyler Allgeier | Atl vs Min |
| 36 | Ezekiel Elliott | NE vs Wsh |
| 37 | Cam Akers | Min @ Atl |
| 38 | Miles Sanders | Car vs Ind |
| 39 | Devin Singletary | Hou vs TB |
| 40 | Tyjae Spears | Ten @ Pit |
