All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 2:00 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF v Dal |
| 2 | Bijan Robinson | Atl vs Hou |
| 3 | Josh Jacobs | LV v GB |
| 4 | Derrick Henry | Ten @ Ind |
| 5 | Tony Pollard | Dal v SF |
| 6 | Alvin Kamara | NO @ NE |
| 7 | Kyren Williams | LAR vs Phi |
| 8 | James Conner | Ari vs Cin |
| 9 | Joe Mixon | Cin @ Ari |
| 10 | Travis Etienne | Jax v Buf |
| 11 | Raheem Mostert | Mia vs NYG |
| 12 | David Montgomery | Det vs Car |
| 13 | Rhamondre Stevenson (GTD) | NE vs NO |
| 14 | D'Andre Swift | Phi @ LAR |
| 15 | Aaron Jones | GB v LV |
| 16 | Brian Robinson Jr. | Wsh v Chi |
| 17 | De'Von Achane | Mia v NYG |
| 18 | James Cook | Buf v Jax |
| 19 | Isiah Pacheco | KC @ Min |
| 20 | Dameon Pierce (GTD) | Hou @ Atl |
| 21 | Jahmyr Gibbs | Det vs Car |
| 22 | Alexander Mattison | Min vs KC |
| 23 | De'Von Achane | Mia vs NYG |
| 24 | Breece Hall | NYJ @ Den |
| 25 | Miles Sanders (GTD) | Car @ Det |
| 26 | Najee Harris | Pit vs Bal |
| 27 | Jaleel McLaughlin | Den vs NYJ |
| 28 | Khalil Herbert | Chi v Wsh |
| Rank | Player | Match |
| 29 | Jaylen Warren | Pit vs Bal |
| 30 | Tyler Allgeier | Atl vs Hou |
| 31 | Gus Edwards | Bal @ Pit |
| 32 | Antonio Gibson | Wsh v Chi |
| 33 | Samaje Perine | Den vs NYJ |
| 34 | Dalvin Cook | NYJ @ Den |
| 35 | A.J. Dillion | GB v LV |
| 36 | Jonathan Taylor (GTD) | Ind vs Ten |
| 37 | Chuba Hubbard | Car @ Det |
| 38 | Tyjae Spears | Ten @ Ind |
| 39 | Zack Moss | Ind vs Ten |
| 40 | Ezekiel Elliott | NE vs NO |
| 41 | Kenneth Gainwell | Phi @ LAR |
| 42 | Saquon Barkley (GTD) | NYG @ Mia |
| 43 | Roshon Johnson | Chi v Wsh |
| 44 | Jerick McKinnon | KC @ Min |
| 45 | Cam Akers | Min vs KC |
| 46 | Zach Moss | Ind v Ten |
| 47 | Javonte Williams (GTD) | Den vs NYJ |
| 48 | Matt Breida | NYG @ Mia |
| 49 | Justice Hill (GTD) | Bal @ Pit |
| 50 | Devin Singletary | Hou @ Atl |
| 51 | Ronnie Rivers | LAR vs Phi |
| 52 | Kendre Miller | NO @ NE |
