All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 10:37 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ LV |
| 2 | Austin Ekeler | LAC vs LAR |
| 3 | Saquon Barkley | NYG vs Ind |
| 4 | James Conner | Ari @ Atl |
| 5 | Dalvin Cook | Min @ GB |
| 6 | Travis Etienne | Jax @ Hou |
| 7 | Joe Mixon | Cin vs Buf |
| 8 | Josh Jacobs | LV vs SF |
| 9 | Rhamondre Stevenson | NE vs Mia |
| 10 | Brian Robinson | Wsh vs Cle |
| 11 | Alvin Kamara | NO @ Phi |
| 12 | Nick Chubb | Cle @ Wsh |
| 13 | Aaron Jones | GB vs Min |
| 14 | Miles Sanders | Phi vs NO |
| 15 | Kenneth Walker III | Sea vs NYJ |
| 16 | Leonard Fournette | TB vs Car |
| 17 | David Montgomery | Chi @ Det |
| 18 | Cam Akers | LAR @ LAC |
| 19 | Tyler Allgeier | Atl vs Ari |
| 20 | D'Andre Swift | Det vs Chi |
| Rank | Player | Match |
| 21 | Najee Harris | Pit @ Bal |
| 22 | Jerick McKinnon | KC vs Den |
| 23 | A.J. Dillon | GB vs Min |
| 24 | Zonovan Knight | NYJ @ Sea |
| 25 | Isiah Pacheco | KC vs Den |
| 26 | Zack Moss | Ind @ NYG |
| 27 | Devin Singletary | Buf @ Cin |
| 28 | J.K. Dobbins | Bal vs Pit |
| 29 | Jamaal Williams | Det vs Chi |
| 30 | Cordarrelle Patterson | Atl vs Ari |
| 31 | D'Onta Foreman | Car @ TB |
| 32 | Rachaad White | TB vs Car |
| 33 | Latavius Murray | Den @ KC |
| 34 | Raheem Mostert | Mia @ NE |
| 35 | Jeff Wilson Jr. | Mia @ NE |
| 36 | Michael Carter | NYJ @ Sea |
| 37 | Chuba Hubbard | Car @ TB |
| 38 | Royce Freeman | Hou vs Jax |
| 39 | James Cook | Buf @ Cin |
| 40 | Samaje Perine | Cin vs Buf |
