All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 10:09 AM ET.
| Rank | Player | Match |
| 1 | Jonathan Taylor | Ind vs KC |
| 2 | Dalvin Cook | Min vs Det |
| 3 | Christian McCaffrey | Car vs NO |
| 4 | Joe Mixon | Cin @ NYJ |
| 5 | Saquon Barkley | NYG vs Dal |
| 6 | Derrick Henry | Ten vs LV |
| 7 | Austin Ekeler | LAC vs Jax |
| 8 | Leonard Fournette | TB vs GB |
| 9 | Nick Chubb | Cle vs Pit |
| 10 | Alvin Kamara (GTD) | NO @ Car |
| 11 | David Montgomery | Chi vs Hou |
| 12 | D'Andre Swift (GTD) | Det @ Min |
| 13 | Aaron Jones | GB @ TB |
| 14 | James Conner (GTD) | Ari vs LAR |
| 15 | Antonio Gibson | Wsh vs Phi |
| 16 | Javonte Williams | Den vs SF |
| 17 | Cordarrelle Patterson | Atl @ Sea |
| 18 | Jeff Wilson | SF @ Den |
| 19 | James Robinson | Jax @ LAC |
| 20 | Miles Sanders | Phi @ Wsh |
| Rank | Player | Match |
| 21 | Ezekiel Elliott | Dal @ NYG |
| 22 | Josh Jacobs (GTD) | LV @ Ten |
| 23 | A.J. Dillon | GB @ TB |
| 24 | Kareem Hunt | Cle vs Pit |
| 25 | Michael Carter | NYJ vs Cin |
| 26 | Clyde Edwards-Helaire | KC @ Ind |
| 27 | Damien Harris | NE vs Bal |
| 28 | Dameon Pierce | Hou @ Chi |
| 29 | Darrell Henderson | LAR @ Ari |
| 30 | Rashaad Penny | Sea vs Atl |
| 31 | Chase Edmonds | Mia vs Buf |
| 32 | Devin Singletary | Buf @ Mia |
| 33 | Tony Pollard | Dal @ NYG |
| 34 | Cam Akers | LAR @ Ari |
| 35 | Raheem Mostert | Mia vs Buf |
| 36 | Breece Hall | NYJ vs Cin |
| 37 | J.K. Dobbins | Bal @ NE |
| 38 | Rhamondre Stevenson | NE vs Bal |
| 39 | Melvin Gordon | Den vs SF |
| 40 | Jamaal Williams | Det @ Min |
