All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:49 AM ET.
| Rank | Player | Match |
| 1 | Austin Ekeler | LAC vs NYG |
| 2 | Alvin Kamara | NO @ NYJ |
| 3 | Leonard Fournette | TB vs Buf |
| 4 | Joe Mixon (GTD) | Cin vs SF |
| 5 | Josh Jacobs | LV @ KC |
| 6 | Aaron Jones | GB vs Chi |
| 7 | Antonio Gibson | Wsh vs Dal |
| 8 | Cordarrelle Patterson | Atl @ Car |
| 9 | Javonte Williams | Den vs Det |
| 10 | Nick Chubb | Cle vs Bal |
| 11 | Saquon Barkley | NYG @ LAC |
| 12 | Ezekiel Elliott | Dal @ Wsh |
| 13 | Sony Michel | LAR @ Ari |
| 14 | David Montgomery | Chi @ GB |
| 15 | James Robinson | Jax @ Ten |
| 16 | Clyde Edwards-Helaire | KC vs LV |
| 17 | James Conner | Ari vs LAR |
| 18 | Devonta Freeman | Bal @ Cle |
| 19 | Kareem Hunt | Cle vs Bal |
| 20 | Chuba Hubbard | Car vs Atl |
| Rank | Player | Match |
| 21 | A.J. Dillon | GB vs Chi |
| 22 | Jeff Wilson | SF @ Cin |
| 23 | Melvin Gordon (GTD) | Den vs Det |
| 24 | Ty Johnson | NYJ vs NO |
| 25 | David Johnson | Hou vs Sea |
| 26 | Jermar Jefferson | Det @ Den |
| 27 | Darrel Williams | KC vs LV |
| 28 | D'Onta Foreman | Ten vs Jax |
| 29 | Dontrell Hilliard | Ten vs Jax |
| 30 | Rex Burkhead | Hou vs Sea |
| 31 | Tony Pollard (GTD) | Dal @ Wsh |
| 32 | JaMycal Hasty | SF @ Cin |
| 33 | Godwin Igwebuike | Det @ Den |
| 34 | Chase Edmonds (GTD) | Ari vs LAR |
| 35 | Devin Singletary | Buf @ TB |
| 36 | Alex Collins | Sea @ Hou |
| 37 | Austin Walter | NYJ vs NO |
| 38 | Rashaad Penny | Sea @ Hou |
| 39 | Matt Breida | Buf @ TB |
| 40 | J.D. McKissic (GTD) | Wsh vs Dal |
