All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 8:52 AM ET.
| Rank | Player | Match |
| 1 | Jonathan Taylor | Ind @ Hou |
| 2 | Joe Mixon | Cin vs LAC |
| 3 | Alexander Mattison | Min @ Det |
| 4 | Austin Ekeler | LAC @ Cin |
| 5 | Najee Harris | Pit vs Bal |
| 6 | Leonard Fournette | TB @ Atl |
| 7 | Javonte Williams | Den @ KC |
| 8 | Antonio Gibson | Wsh @ LV |
| 9 | James Conner | Ari @ Chi |
| 10 | Eli Mitchell | SF @ Sea |
| 11 | Saquon Barkley | NYG @ Mia |
| 12 | Darrell Henderson (GTD) | LAR vs Jax |
| 13 | Cordarrelle Patterson | Atl vs TB |
| 14 | Josh Jacobs (GTD) | LV vs Wsh |
| 15 | Myles Gaskin | Mia vs NYG |
| 16 | David Montgomery | Chi vs Ari |
| 17 | James Robinson (GTD) | Jax @ LAR |
| 18 | Jamaal Williams | Det vs Min |
| 19 | Miles Sanders | Phi @ NYJ |
| 20 | Clyde Edwards-Helaire (GTD) | KC vs Den |
| Rank | Player | Match |
| 21 | Devonta Freeman | Bal @ Pit |
| 22 | Darrel Williams | KC vs Den |
| 23 | Rex Burkhead | Hou vs Ind |
| 24 | Tevin Coleman | NYJ vs Phi |
| 25 | Boston Scott (GTD) | Phi @ NYJ |
| 26 | Damien Harris | NE @ Buf |
| 27 | Devin Singletary | Buf vs NE |
| 28 | Rhamondre Stevenson | NE @ Buf |
| 29 | Kenyan Drake | LV vs Wsh |
| 30 | Ty Johnson | NYJ vs Phi |
| 31 | Sony Michel | LAR vs Jax |
| 32 | Alex Collins (GTD) | Sea vs SF |
| 33 | Matt Breida | Buf vs NE |
| 34 | Jeff Wilson | SF @ Sea |
| 35 | Mike Davis | Atl vs TB |
| 36 | Nyheim Hines | Ind @ Hou |
| 37 | Latavius Murray | Bal @ Pit |
| 38 | Ronald Jones | TB @ Atl |
| 39 | Jermar Jefferson | Det vs Min |
| 40 | Samaje Perine | Cin vs LAC |
